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Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes
- Source :
- ACS Macro Letters. 5:1132-1136
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- There is a growing need for the development of nanoparticles, with imaging and drug delivery capabilities, to maintain cellular uptake but avoid protein attachment and recognition. In this study we have demonstrated that nanoparticles consisting of a poly(glycidyl methacrylate) (PGMA) core and a mixed brush architecture of methoxypoly(ethylene glycol) and poly(ethylenimine) (mPEG-PEI) on the surface can meet this need. Surface functionalization with PEI alone results in cellular uptake, but rapid protein attachment whereas PEG alone can avoid protein attachment but to the detriment of cellular uptake. A mixed copolymer brush of both PEI and mPEG provides the ideal balance.
- Subjects :
- Glycidyl methacrylate
Materials science
Polymers and Plastics
Nanoparticle
macromolecular substances
02 engineering and technology
010402 general chemistry
01 natural sciences
Inorganic Chemistry
chemistry.chemical_compound
PEG ratio
Polymer chemistry
Materials Chemistry
Copolymer
chemistry.chemical_classification
Organic Chemistry
technology, industry, and agriculture
Polymer
021001 nanoscience & nanotechnology
0104 chemical sciences
chemistry
Chemical engineering
Drug delivery
Surface modification
0210 nano-technology
Ethylene glycol
Subjects
Details
- ISSN :
- 21611653
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- ACS Macro Letters
- Accession number :
- edsair.doi.dedup.....b7cacb5fcbab881cb408d2c0ed078475