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Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application
- Source :
- Journal of controlled release : official journal of the Controlled Release Society. 176
- Publication Year :
- 2013
-
Abstract
- Red blood cells (RBCs) based drug carrier appears to be the most appealing for protein drugs due to their unmatched biocompatability, biodegradability, and long lifespan in the circulation. Numerous methods for encapsulating protein drugs into RBCs were developed, however, most of them induce partial disruption of the cell membrane, resulting in irreversible alterations in both physical and chemical properties of RBCs. Herein, we introduce a novel method for encapsulating proteins into intact RBCs, which was meditated by a cell penetrating peptide (CPP) developed in our lab-low molecular weight protamine (LMWP). l-asparaginase, one of the primary drugs used in treatment of acute lymphoblastic leukemia (ALL), was chosen as a model protein to illustrate the encapsulation into erythrocytes mediated by CPPs. In addition current treatment of ALL using different l-asparaginase delivery and encapsulation methods as well as their associated problems were also reviewed.
- Subjects :
- Drug Carriers
Protein therapeutics
Erythrocytes
biology
Lymphoblastic Leukemia
Cell
Pharmaceutical Science
Model protein
Antineoplastic Agents
Cell-Penetrating Peptides
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protamine
Article
Cell biology
Cell membrane
medicine.anatomical_structure
Biochemistry
hemic and lymphatic diseases
medicine
Cell-penetrating peptide
biology.protein
Animals
Asparaginase
Humans
Drug carrier
Subjects
Details
- ISSN :
- 18734995
- Volume :
- 176
- Database :
- OpenAIRE
- Journal :
- Journal of controlled release : official journal of the Controlled Release Society
- Accession number :
- edsair.doi.dedup.....b7abc5e5a6c7d5706495d237269a03c8