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Prenatal Stress Inhibits Neuronal Maturation through Downregulation of Mineralocorticoid Receptors
- Source :
- The Journal of Neuroscience. 31:11505-11514
- Publication Year :
- 2011
- Publisher :
- Society for Neuroscience, 2011.
-
Abstract
- Prenatal stress (PS) increases the risk of depressive disorders in adult offspring. The pathophysiology of depressive disorders has been linked to hippocampal dysfunction; however, whether and how PS attenuates the development and function of hippocampal networks remains unknown. Using a rat model of PS, in which pregnant mothers receive daily restraint stress during late gestation and their offspring exhibit depressive-like behavior later in life, we show that PS impairs the morphological and functional maturation of hippocampal granule cells in adult offspring via the downregulated expression of mineralocorticoid receptors. PS reduced the dendritic complexity and spine density of neonatal-generated granule cells, which persists into adulthood. These granule cells exhibited depressed synaptic responses to stimulation of the medial perforant path. We further revealed that the expression of mineralocorticoid receptors, which we found is necessary for proper dendritic maturation in this study, was significantly downregulated in granule cells after PS. These results suggest that PS-induced downregulation of mineralocorticoid receptors attenuates neuronal maturation, which results in dysfunction of neuronal network in adulthood.
- Subjects :
- medicine.medical_specialty
Offspring
medicine.drug_class
Neurogenesis
Down-Regulation
Stimulation
Hippocampal formation
Biology
Mineralocorticoid receptor
Pregnancy
Internal medicine
medicine
Animals
Rats, Wistar
Receptor
Mineralocorticoid Receptor Antagonists
Neurons
General Neuroscience
Neural Inhibition
Articles
Perforant path
Rats
Pregnancy Complications
Receptors, Mineralocorticoid
Endocrinology
medicine.anatomical_structure
Animals, Newborn
Prenatal stress
Mineralocorticoid
Prenatal Exposure Delayed Effects
Female
Stress, Psychological
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....b7ab73662ed0a9d100d6d43e22bf6d71