Back to Search
Start Over
Time course of infarct healing and left ventricular remodelling in patients with reperfused ST segment elevation myocardial infarction using comprehensive magnetic resonance imaging
- Source :
- European Radiology. 21:693-701
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- To describe the time course of myocardial infarct (MI) healing and left ventricular (LV) remodelling and to assess factors predicting LV remodelling using cardiac MRI.In 58 successfully reperfused MI patients, MRI was performed at baseline, 4 months (4M), and 1 year (1Y) post MI RESULTS: Infarct size decreased between baseline and 4M (p0.001), but not at 1Y; i.e. 18 ± 11%, 12 ± 8%, 11 ± 6% of LV mass respectively; this was associated with LV mass reduction. Infarct and adjacent wall thinning was found at 4M, whereas significant remote wall thinning was measured at 1Y. LV end-diastolic and end-systolic volumes significantly increased at 1Y, p0.05 at 1Y vs. baseline and vs. 4M; this was associated with increased LV sphericity index. No regional or global LV functional improvement was found at follow-up. Baseline infarct size was the strongest predictor of adverse LV remodelling.Infarct healing, with shrinkage of infarcted myocardium and wall thinning, occurs early post-MI as reflected by loss in LV mass and adjacent myocardial remodelling. Longer follow-up demonstrates ongoing remote myocardial and ventricular remodelling. Infarct size at baseline predicts long-term LV remodelling and represents an important parameter for tailoring future post-MI pharmacological therapies designed to prevent heart failure.
- Subjects :
- Adult
Male
Infarct healing
medicine.medical_specialty
Time Factors
Systole
Myocardial Infarction
Diastole
Internal medicine
medicine
Humans
ST segment
Radiology, Nuclear Medicine and imaging
cardiovascular diseases
Myocardial infarction
Angioplasty, Balloon, Coronary
Aged
Neuroradiology
Heart Failure
Ventricular Remodeling
medicine.diagnostic_test
business.industry
Myocardium
Electrocardiography in myocardial infarction
Interventional radiology
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Radiography
Time course
cardiovascular system
Cardiology
Female
Radiology
business
Subjects
Details
- ISSN :
- 14321084 and 09387994
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- European Radiology
- Accession number :
- edsair.doi.dedup.....b7a1d17fcb8d5f023e262c71577aed35