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MAXIMAL LOCAL AND MINIMAL SYSTEMIC CYTOKINE RESPONSE TO COLORECTAL SURGERY: THE INFLUENCE OF PERIOPERATIVE FILGRASTIM
- Source :
- Cytokine. 14:188-192
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- Thirty consecutive patients scheduled for elective colorectal surgery were prospectively randomized to receive either filgrastim [the recombinant human form of granulocyte colony-stimulating factor (r-metHu-G-CSF)] or placebo blindly. The levels of interleukin (IL-)1beta, tumour necrosis factor-alpha (TNF-alpha), IL-6, IL-8, transforming growth factor-beta (TGF-beta), and IL-10 were determined 5 and 24 h postoperatively from peripheral blood, peritoneal fluid, and wound fluid. The concentrations of all the measured cytokines were enormously higher locally at the operative site than in the systemic circulation. The only difference between the two medication groups was the lower concentration of IL-8 in peripheral blood in the filgrastim-treated patients. The present study shows abundant release of pro- and anti-inflammatory cytokines into the wound and the peritoneal cavity after abdominal surgery. The systemic response to surgery seems to be a secondary and minor reflection of local events. Filgrastim did not have any effect on the studied local cytokine levels at the operative site.
- Subjects :
- Male
medicine.medical_specialty
Filgrastim
Injections, Subcutaneous
medicine.medical_treatment
Immunology
Biochemistry
Gastroenterology
Drug Administration Schedule
Perioperative Care
Placebos
Peritoneal cavity
Double-Blind Method
Internal medicine
Granulocyte Colony-Stimulating Factor
medicine
Humans
Immunology and Allergy
Postoperative Period
Prospective Studies
Molecular Biology
business.industry
Peritoneal fluid
Interleukin
Hematology
Perioperative
Middle Aged
Recombinant Proteins
Colorectal surgery
Surgery
medicine.anatomical_structure
Cytokine
Cytokines
Female
business
Colorectal Surgery
Abdominal surgery
medicine.drug
Subjects
Details
- ISSN :
- 10434666
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Cytokine
- Accession number :
- edsair.doi.dedup.....b77c064f74bbe73e50a2f244e9fafb0c