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Long-Term in Vivo Clearance of Gadolinium-Based AGuIX Nanoparticles and Their Biocompatibility after Systemic Injection
- Source :
- ACS Nano, ACS Nano, American Chemical Society, 2015, 9 (3), pp.2477-2488. ⟨10.1021/acsnano.5b00552⟩, ACS Nano, 2015, 9 (3), pp.2477-2488. ⟨10.1021/acsnano.5b00552⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- International audience; We previously reported the synthesis of gadolinium-based nanoparticles (NPs) denoted AGuIX (activation and guiding of irradiation by X-ray) NPs and demonstrated their potential as an MRI contrast agent and their efficacy as radiosensitizing particles during X-ray cancer treatment. Here we focus on the elimination kinetics of AGuIX NPs from the subcellular to whole-organ scale using original and complementary methods such as laser-induced breakdown spectroscopy (LIBS), intravital two-photon microscopy, inductively coupled plasma optical emission spectrometry (ICP-OES), transmission electron microscopy (TEM), and electrospray ionization mass spectrometry (ESI-MS). This combination of techniques allows the exact mechanism of AGuIX NPs elimination to be elucidated, including their retention in proximal tubules and their excretion as degraded or native NPs. Finally, we demonstrated that systemic AGuIX NP administration induced moderate and transient effects on renal function. These results provide useful and promising preclinical information concerning the safety of theranostic AGuIX NPs.
- Subjects :
- Models, Molecular
Materials science
Kidney Cortex
Biocompatibility
MRI contrast agent
Electrospray ionization
Gadolinium
Molecular Conformation
General Physics and Astronomy
Nanoparticle
chemistry.chemical_element
Contrast Media
Metal Nanoparticles
Biocompatible Materials
[SDV.CAN]Life Sciences [q-bio]/Cancer
02 engineering and technology
010402 general chemistry
01 natural sciences
Injections
Mice
Nuclear magnetic resonance
Two-photon excitation microscopy
[SDV.CAN] Life Sciences [q-bio]/Cancer
In vivo
Animals
Humans
General Materials Science
Laser-induced breakdown spectroscopy
X-Rays
General Engineering
technology, industry, and agriculture
Biological Transport
021001 nanoscience & nanotechnology
0104 chemical sciences
3. Good health
Kinetics
chemistry
Biophysics
Safety
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 19360851
- Database :
- OpenAIRE
- Journal :
- ACS Nano, ACS Nano, American Chemical Society, 2015, 9 (3), pp.2477-2488. ⟨10.1021/acsnano.5b00552⟩, ACS Nano, 2015, 9 (3), pp.2477-2488. ⟨10.1021/acsnano.5b00552⟩
- Accession number :
- edsair.doi.dedup.....b77ab4acb10b37eec6206d72c43e0e49