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Vitamin D and the risk of dystocia:A case-control study
- Source :
- Thomsen, C R, Milidou, I, Hvidman, L, Khalil, M R, Rejnmark, L & Uldbjerg, N 2020, ' Vitamin D and the risk of dystocia : A case-control study ', PLOS ONE, vol. 15, no. 10, e0240406 . https://doi.org/10.1371/journal.pone.0240406, PLoS ONE, PLoS ONE, Vol 15, Iss 10, p e0240406 (2020)
- Publication Year :
- 2020
-
Abstract
- BackgroundDystocia is one of the most common causes of cesarean section in nulliparous women. Studies have described the presence of vitamin D receptors in the myometrium, but it is still unclear whether vitamin D affects the contractility of the smooth muscles. We therefore aimed to determine the association between the vitamin D serum level at labor and the risk of dystocia.MethodWe conducted a case-control study between January 2012 and June 2017. Cases were primiparous women, with spontaneous onset of labor, who gave birth by cesarean section due to dystocia. Controls were primiparous women with a spontaneous vaginal delivery. We included 60 women (30 cases and 30 controls) in the analysis. The differences between cases and controls were assessed using chi-squared test for categorical variables and two-sample t-test or unequal t-test for continuous variables, as appropriate, after evaluation of whether they followed the normal distributions.ResultsThe mean serum 25-hydroxyvitamin D concentrations were 53.1nmol/l (95%CI; 45.2 to 60.9) among cases and 69.9nmol/l (95%CI; 57.5 to 82.4) among controls (P = 0.02). The mean plasma parathyroid hormone levels were 2.25 pmol/l and 2.38, respectively (P = 0.57). Even though 78% of all women reported taking a minimum of 10μg/day of vitamin D throughout pregnancy, 43% had vitamin D insufficiency, defined as serum 25-hydroxyvitamin D levels below 50nmol/l.ConclusionsIn a Danish group of women having a cesarean section due to dystocia, we found decreased vitamin D levels.
- Subjects :
- Epidemiology
Maternal Health
Denmark
Parathyroid hormone
Organic chemistry
Epidural Block
Continuous variable
Labor and Delivery
0302 clinical medicine
Pregnancy
Anesthesiology
Medicine and Health Sciences
Medicine
Anesthesia
030212 general & internal medicine
Vitamin D
reproductive and urinary physiology
030219 obstetrics & reproductive medicine
Multidisciplinary
Obstetrics
Pharmaceutics
Myometrium
Obstetrics and Gynecology
Vitamins
Physical sciences
Chemistry
Obstetric Procedures
Research Design
Parathyroid Hormone
Female
Research Article
Maternal Age
Adult
medicine.medical_specialty
Spontaneous vaginal delivery
Science
Surgical and Invasive Medical Procedures
Research and Analysis Methods
Contractility
03 medical and health sciences
Chemical compounds
Drug Therapy
Organic compounds
Vitamin D and neurology
Humans
business.industry
Cesarean Section
Case-control study
medicine.disease
Vitamin D Deficiency
Dystocia
Case-Control Studies
Medical Risk Factors
Birth
Women's Health
Labor Onset
Local and Regional Anesthesia
Analgesia
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Thomsen, C R, Milidou, I, Hvidman, L, Khalil, M R, Rejnmark, L & Uldbjerg, N 2020, ' Vitamin D and the risk of dystocia : A case-control study ', PLOS ONE, vol. 15, no. 10, e0240406 . https://doi.org/10.1371/journal.pone.0240406, PLoS ONE, PLoS ONE, Vol 15, Iss 10, p e0240406 (2020)
- Accession number :
- edsair.doi.dedup.....b76f903f75f96e81699e00221d5a5ecb