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Therapeutic efficacy of amoxicillin and rifaximin in patients with small intestinal bacterial overgrowth and Helicobacter pylori infection
- Source :
- Gastroenterology Review, Vol 13, Iss 3, Pp 213-217 (2018)
- Publication Year :
- 2018
- Publisher :
- Termedia Sp. z.o.o., 2018.
-
Abstract
- Introduction Small intestinal bacterial overgrowth (SIBO) may coexist with Helicobacter pylori infection, which can be the cause of chronic gastrointestinal complaints. Aim Evaluation of the therapeutic efficacy of amoxicillin and rifaximin in the treatment of these diseases. Material and methods The lactulose hydrogen breath test (LHBT) and the urea breath test (13C-UBT) were performed in 116 patients. In 62 patients the coexistence of small intestinal bacterial overgrowth and H. pylori infection was observed. Then, in group I (n = 30) pantoprazole (2 × 40 mg), amoxicillin (2 × 1000 mg) and metronidazole (2 × 500 mg) and in group II (n = 32) pantoprazole and amoxicillin at the above doses and rifaximin (3 × 400 mg) were administered for 10 days. After 6 weeks, both breath tests were repeated and the degree of remission of symptoms was measured using a 10-point visual analog scale (VAS). Results After the treatment the LHBT index decreased in group I from 61.2 ±19.4 ppm to 22.0 ±8.2 ppm (p 0.05). The decrease of pain below 3.0 points in the VAS was obtained in 64.8% of patients in group I and in 56.2% in group II. Conclusions Combination of amoxicillin and rifaximin may be effective in the treatment of patients with small intestinal bacterial overgrowth syndrome and concomitant H. pylori infection.
- Subjects :
- medicine.medical_specialty
Urea breath test
lcsh:Medicine
small intestinal bacterial overgrowth
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
Lactulose
0302 clinical medicine
Internal medicine
Small intestinal bacterial overgrowth
medicine
Pantoprazole
therapy
amoxicillin
medicine.diagnostic_test
biology
business.industry
lcsh:R
Helicobacter pylori
Amoxicillin
medicine.disease
biology.organism_classification
Rifaximin
rifaximin
chemistry
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
business
Hydrogen breath test
medicine.drug
Subjects
Details
- ISSN :
- 18955770
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Gastroenterology Review
- Accession number :
- edsair.doi.dedup.....b76a9a4a19d9132ae313dd08c988b20b