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Thymic enlargement in a patient with juvenile idiopathic arthritis during etanercept therapy
- Publication Year :
- 2009
-
Abstract
- Tumor necrosis factor (TNF) alpha inhibitors are effective in the treatment of inflammatory rheumatic diseases. Despite their effectiveness, anti-TNF drugs have some drawbacks such as severe adverse effects including infections and possibly lymphoproliferative disorders. In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment. The clinical presentation was highly suggestive of malignancy and the patient underwent diagnostic mediastinoscopy with biopsy.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Time Factors
Mediastinal lymphadenopathy
Recombinant Fusion Proteins
Immunology
Lymphoproliferative disorders
Arthritis
Thymus Gland
Malignancy
Gastroenterology
Mediastinal Neoplasms
Receptors, Tumor Necrosis Factor
True Thymic Hyperplasia
Etanercept
Diagnosis, Differential
Young Adult
Rheumatology
Internal medicine
medicine
Immunology and Allergy
Humans
Immunologic Factors
Lymphatic Diseases
Mediastinoscopy
business.industry
medicine.disease
Arthritis, Juvenile
Treatment Outcome
Pleurisy
Antirheumatic Agents
Immunoglobulin G
business
Tomography, X-Ray Computed
medicine.drug
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b768079a8fa4655614139a7a890677d0