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Epicardium-derived fibroblasts in heart development and disease
- Publication Year :
- 2015
-
Abstract
- The majority of cardiac fibroblasts in a mature mammalian heart are derived from the epicardium during prenatal development and reactivate developmental programs during the progression of fibrotic disease. In addition, epicardial activation, proliferation, and fibrosis occur with ischemic, but not hypertensive injury. Here we review cellular and molecular mechanisms that control epicardium-derived cell lineages during development and disease with a focus on cardiac fibroblasts. This article is part of a special issue entitled "Fibrosis and Myocardial Remodeling".
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Cardiac fibrosis
Cellular differentiation
Organogenesis
Myocardial Infarction
Article
Extracellular matrix
03 medical and health sciences
Fibrosis
medicine
Animals
Humans
Cell Lineage
Myocytes, Cardiac
Myocardial infarction
Epithelial–mesenchymal transition
Molecular Biology
Cell Proliferation
Heart development
business.industry
Myocardium
Cell Differentiation
Fibroblasts
medicine.disease
Hypertensive heart disease
030104 developmental biology
cardiovascular system
Cardiology and Cardiovascular Medicine
business
Pericardium
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b75b6469c3012a118acd07bfd6af799c