Effect of Somatostatin and Dopaminergic Agents on Bovine Pituitary Phosphodiesterase Activity

Authors :: Hiroyoshi Hidaka
Akio Nagasaka
Rumi Masunaga
Hifumi Nakagawa
Akira Nakai
Katsumi Iwase
Takako Ohyama
Toshihiro Aono
Source :: Neuroendocrinology. 43:410-415
Publication Year :: 1986
Publisher :: S. Karger AG, 1986.
Abstract: The effects of somatostatin and dopaminergic agents on pituitary cyclic nucleotide phosphodiesterases that had been partially purified through DEAE cellulose column chromatography were studied. Somatostatin, L-dopa, dopamine and CB-154(2-bromo-alpha-ergocriptine) competitively inhibited the pituitary cyclic AMP phosphodiesterase activity, especially that of the low Km enzyme. This inhibition was most potent in the case of somatostatin and CB-154.

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