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The Differential Expression of Immune Genes between Water Buffalo and Yellow Cattle Determines Species-Specific Susceptibility to Schistosoma japonicum Infection
- Source :
- PLoS ONE, PLoS ONE, Vol 10, Iss 6, p e0130344 (2015)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLoS), 2015.
-
Abstract
- Water buffalo are less susceptible to Schistosoma japonicum infection than yellow cattle. The factors that affect such differences in susceptibility remain unknown. A Bos taurus genome-wide gene chip was used to analyze gene expression profiles in the peripheral blood of water buffalo and yellow cattle pre- and post-infection with S. japonicum. This study showed that most of the identified differentially expressed genes (DEGs) between water buffalo and yellow cattle pre- and post-infection were involved in immune-related processes, and the expression level of immune genes was lower in water buffalo. The unique DEGs (390) in yellow cattle were mainly associated with inflammation pathways, while the unique DEGs (2,114) in water buffalo were mainly associated with immune-related factors. The 83 common DEGs may be the essential response genes during S. japonicum infection, the highest two gene ontology (GO) functions were associated with the regulation of fibrinolysis. The pathway enrichment analysis showed that the DEGs constituted similar immune-related pathways pre- and post-infection between the two hosts. This first analysis of the transcriptional profiles of natural hosts has enabled us to gain new insights into the mechanisms that govern their susceptibility or resistance to S. japonicum infections.
- Subjects :
- Male
Buffaloes
animal diseases
lcsh:Medicine
Cattle Diseases
Biology
Real-Time Polymerase Chain Reaction
Schistosoma japonicum
Host-Parasite Interactions
Transcriptome
Species Specificity
parasitic diseases
Gene expression
Animals
Genetic Predisposition to Disease
RNA, Messenger
lcsh:Science
Gene
Schistosoma
Genetics
Multidisciplinary
Schistosoma Japonicum Infection
lcsh:R
food and beverages
biology.organism_classification
Gene Ontology
Schistosomiasis japonica
lcsh:Q
Cattle
DNA microarray
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....b7537d5854e37da0438b89ef94c433fc