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High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders
- Source :
- CNS Neuroscience & Therapeutics
- Publication Year :
- 2014
-
Abstract
- Source at https://doi.org/10.1111/cns.12303. Aims - As major depression (MD) is often comorbid with alcohol‐use disorders (AUD) and alcohol itself modulates the immune system, we examined serum levels of interleukin (IL)‐6, IL‐10, tumor necrosis factor (TNF), and interferon (IFN)‐γ in AUD patients with and without MD. Putative interactions between alcohol variables and MD on cytokine levels were also assessed. Methods - A consecutive sample of inpatients with AUD (N = 176) from eight alcohol treatment centers in Kathmandu, Nepal, was assessed for alcohol use and depression by administering fully structured psychiatric interviews. Serum cytokine levels were determined using multiplex technology. Results - Alcohol‐use disorders patients with a positive history of MD had higher levels of the inflammatory cytokines IL‐6 (P = 0.019), TNF (P = 0.020), and IFN‐γ (P = 0.001), but not of IL‐10 (P = 0.853). AUD patients with MD had higher concentrations of cytokines compared with those without, regardless of the severity of the alcohol problem, but the difference was greater among those drinking in lower frequency and intensity. Conclusion - These findings provide evidence for altered functioning of the immune system in AUD patients with comorbid MD. However, frequent and intense drinking may attenuate the difference in the cytokine profiles between AUD patients with and without MD.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Samfunnsmedisin, sosialmedisin: 801 [VDP]
medicine.medical_treatment
VDP::Community medicine, social medicine: 801
Poison control
Gastroenterology
Article
Proinflammatory cytokine
Community medicine, social medicine: 801 [VDP]
Immune system
Nepal
Physiology (medical)
Internal medicine
mental disorders
Medicine
Humans
Pharmacology (medical)
VDP::Medisinske fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801
Depression (differential diagnoses)
Alcohol
Comorbidity
Cytokines
Depression
Immune activation
Pharmacology
Psychiatric Status Rating Scales
VDP::Midical sciences: 700::Health sciences: 800::Community medicine, social medicine: 801
Depressive Disorder, Major
business.industry
Interleukin
Middle Aged
medicine.disease
Psychiatry and Mental health
Alcoholism
Cytokine
VDP::Samfunnsmedisin, sosialmedisin: 801
Cross-Sectional Studies
Alcohols
Case-Control Studies
Tumor necrosis factor alpha
Female
business
Subjects
Details
- ISSN :
- 17555949 and 17555930
- Volume :
- 20
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- CNS neurosciencetherapeutics
- Accession number :
- edsair.doi.dedup.....b74d0c0634b5f79fdc253952f54cc605