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Immune system and gut microbiota senescence in elderly IBD patients
- Source :
- Minerva gastroenterology.
- Publication Year :
- 2021
-
Abstract
- In inflammatory bowel disease (IBD), the loss of immune tolerance against gut microbiota causes chronic inflammation and the progressive accumulation of organ damage in genetically susceptible individuals. In the elderly, IBD is often characterized by a different disease behaviour when compared with paediatric and young adult disease. Besides disease behaviour, another aspect of the multifaceted impact of age on elderly IBD course is increased susceptibility to infections. In this context, age-of-onset-dependent IBD behaviour and clinical course are two major contributors to immune system senescence and change of gut microbiota in older subjects. Here, we review the available literature linking immunosenescence and age-dependent changes in the gut microbiota composition to IBD pathogenesis speculating on their possible implications in disease expression in this age class.
- Subjects :
- Senescence
biology
business.industry
Endocrinology, Diabetes and Metabolism
Gastroenterology
Context (language use)
Immunosenescence
Disease
Gut flora
medicine.disease
biology.organism_classification
digestive system
Inflammatory bowel disease
digestive system diseases
Immune tolerance
Immune system
Immunology
Internal Medicine
medicine
business
Subjects
Details
- ISSN :
- 27245365
- Database :
- OpenAIRE
- Journal :
- Minerva gastroenterology
- Accession number :
- edsair.doi.dedup.....b74680ad76a8609cc99648383606c139