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Common variants of eNOS and XRCC1 genes may predict acute skin toxicity in breast cancer patients receiving radiotherapy after breast conserving surgery
- Source :
- Radiotherapy and Oncology. 103:199-205
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Purpose: To evaluate the impact of functional polymorphisms in genes related to DNA repair mechanisms (XRCC1, TP53, MSH2, MSH3, XPD), oxidative stress response (GSTP1, GSTA1, eNOS, SOD2) and fibroblast proliferation (TGFb1) on the risk of acute skin toxicity in breast cancer patients receiving radiotherapy. Material and methods: Skin toxicity was scored according to the Radiation Therapy Oncology Group criteria in 286 breast cancer patients who received radiotherapy after breast conserving surgery. Genotyping was conducted by PCR-RFLP analysis and real-time PCR allelic discrimination assay on genomic DNA extracted from peripheral blood. Results: In the multivariate analysis, nominally significant associations, before multiple testing corrections, were found between XRCC1 T-77C (T carriers vs. CC, OR: 2.240, 95% CI: 1.015–4.941, P = 0.046), eNOS G894T polymorphisms (TT vs. G carriers, OR: 2.473, 95% CI: 1.220–5.012, P = 0.012), breast diameter (OR: 1.138, 95% CI: 1.001–1.293, P = 0.048), boost dose-fractionation (3 Gy vs. no boost, OR: 4.902, 95% CI: 1.458–16.483, P = 0.010) and Pgrade 2 acute radiation skin toxicity in breast cancer patients. Conclusions: As our exploratory study suggests that XRCC1 T-77C and eNOS G874T may confer an increased risk of acute skin reactions to radiotherapy in breast cancer patients, further confirmatory studies are warranted to determine the clinical significance.
- Subjects :
- Oncology
medicine.medical_specialty
Genotype
Nitric Oxide Synthase Type III
medicine.medical_treatment
Breast Neoplasms
Mastectomy, Segmental
Polymorphism, Single Nucleotide
Acute skin reaction
Breast cancer
Radiotherapy
Single nucleotide polymorphisms
GSTP1
Enos
Internal medicine
Breast-conserving surgery
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Clinical significance
Aged
Retrospective Studies
Skin
biology
business.industry
Hematology
Middle Aged
medicine.disease
biology.organism_classification
DNA-Binding Proteins
Radiation therapy
X-ray Repair Cross Complementing Protein 1
MSH2
Toxicity
Female
Dose Fractionation, Radiation
business
Subjects
Details
- ISSN :
- 01678140
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Radiotherapy and Oncology
- Accession number :
- edsair.doi.dedup.....b741947a8cddb94b92772b3332ac3bba