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Mitotic spindle (DIS)orientation and DISease: Cause or consequence?
- Source :
- The Journal of Cell Biology, 199 (7), The Journal of Cell Biology, JOURNAL OF CELL BIOLOGY
- Publication Year :
- 2012
- Publisher :
- Rockefeller University Press, 2012.
-
Abstract
- Correct alignment of the mitotic spindle during cell division is crucial for cell fate determination, tissue organization, and development. Mutations causing brain diseases and cancer in humans and mice have been associated with spindle orientation defects. These defects are thought to lead to an imbalance between symmetric and asymmetric divisions, causing reduced or excessive cell proliferation. However, most of these disease-linked genes encode proteins that carry out multiple cellular functions. Here, we discuss whether spindle orientation defects are the direct cause for these diseases, or just a correlative side effect.<br />The Journal of Cell Biology, 199 (7)<br />ISSN:0021-9525<br />ISSN:1540-8140
- Subjects :
- Cell division
Mitosis
Reviews
Spindle Apparatus
Review
Biology
Cell fate determination
Spindle pole body
03 medical and health sciences
0302 clinical medicine
Neural Stem Cells
Animals
Humans
030304 developmental biology
Centrosome
0303 health sciences
Cell Polarity
Cell Biology
Cell biology
Spindle apparatus
Spindle checkpoint
Cell Transformation, Neoplastic
Nervous System Diseases
Multipolar spindles
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 00219525 and 15408140
- Database :
- OpenAIRE
- Journal :
- The Journal of Cell Biology, 199 (7), The Journal of Cell Biology, JOURNAL OF CELL BIOLOGY
- Accession number :
- edsair.doi.dedup.....b741207bb084994a508629bd268f0582