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Overexpression of the phosphoprotein enriched in diabetes gene product (Ped/pea-15) in women with polycystic ovary syndrome
- Source :
- Clinical endocrinology (Oxf., Print) 67 (2007): 557–562. doi:10.1111/j.1365-2265.2007.02924.x, info:cnr-pdr/source/autori:S.Savastano; F.Orio; S.Palomba; T.Cascella; G.A.Lupoli; P.Formisano; G.Lombardi; A.M.Colao; F.Beguinot; R.Valentino/titolo:Overexpression of the phosphoprotein enriched in diabetes gene product (PED%2FPEA15) in women with polycistic ovary sindrome./doi:10.1111%2Fj.1365-2265.2007.02924.x/rivista:Clinical endocrinology (Oxf., Print)/anno:2007/pagina_da:557/pagina_a:562/intervallo_pagine:557–562/volume:67
- Publication Year :
- 2007
-
Abstract
- OBJECTIVE To evaluate Ped/pea-15 (phosphoprotein enriched in diabetes) expression in polycystic ovary syndrome (PCOS) women. DESIGN AND PATIENTS Thirty PCOS women were studied and compared with other 30 age- and body mass index (BMI)-matched women, considered as the control group. Both patients and controls were divided according to BMI. All subjects underwent endocrine and metabolic investigation and Ped/pea-15 expression was evaluated by western blot analysis. Insulin resistance was assessed by HOMA model and insulin sensitivity index (ISI) composite. RESULTS Insulin resistance, evaluated by HOMA-R and ISI composite, was significantly higher in PCOS women and in obese controls than in normal weight controls. Ped/pea-15 expression (%) was higher in PCOS women than in controls (440.4 +/- 220.7 vs. 163.0 +/- 45.5; P < 0.001; range 145.5-987% and 97-281%, respectively), and was positively correlated with insulin, BMI, total testosterone, HOMA index, and family history (P < 0.001). In patients with PCOS univariate analysis of variance showed no effect of BMI variation (P = 0.13) on Ped/pea-15 expression levels. On multiple linear regression analysis, the major determinants of Ped/pea-15 overexpression were family history, insulin, and PCOS status independent of BMI. CONCLUSION These preliminary data (1) highlight the overexpression of Ped/pea-15 in PCOS compared to normal controls, independent of obesity; (2) suggest that Ped/pea-15 overexpression might be an early component of the metabolic syndrome in PCOS; and (3) support the hypothesis that Ped/pea-15 represents a possible useful tool to assess the presence of a genetic condition associated with insulin resistance in PCOS.
- Subjects :
- Adult
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Blotting, Western
Biology
Body Mass Index
Endocrinology
Insulin resistance
Diabetes mellitus
Internal medicine
medicine
Humans
Insulin
Testosterone
Obesity
Univariate analysis
Intracellular Signaling Peptides and Proteins
nutritional and metabolic diseases
medicine.disease
Phosphoproteins
Polycystic ovary
Case-Control Studies
Multivariate Analysis
Female
Metabolic syndrome
Insulin Resistance
Apoptosis Regulatory Proteins
Body mass index
Biomarkers
Polycystic Ovary Syndrome
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Clinical endocrinology (Oxf., Print) 67 (2007): 557–562. doi:10.1111/j.1365-2265.2007.02924.x, info:cnr-pdr/source/autori:S.Savastano; F.Orio; S.Palomba; T.Cascella; G.A.Lupoli; P.Formisano; G.Lombardi; A.M.Colao; F.Beguinot; R.Valentino/titolo:Overexpression of the phosphoprotein enriched in diabetes gene product (PED%2FPEA15) in women with polycistic ovary sindrome./doi:10.1111%2Fj.1365-2265.2007.02924.x/rivista:Clinical endocrinology (Oxf., Print)/anno:2007/pagina_da:557/pagina_a:562/intervallo_pagine:557–562/volume:67
- Accession number :
- edsair.doi.dedup.....b74085ed432c814078be951d7f4ca694