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Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping
- Source :
- Hypertension
- Publication Year :
- 2019
-
Abstract
- Adrenal vein sampling (AVS) is required to distinguish unilateral from bilateral aldosterone sources in primary aldosteronism (PA), and cortisol is used for AVS data interpretation, but cortisol has several pitfalls. In this study, we present the utility of several other steroids in PA subtyping, both during AVS, as well as in peripheral serum. We included patients with PA who underwent AVS at University of Michigan between 2012 and 2018. We used mass spectrometry to simultaneously quantify 17 steroids in adrenal veins (AV) and periphery, both at baseline and after cosyntropin administration. PA was classified as unilateral or bilateral based on a lateralization index ≥ or P
- Subjects :
- Adult
Male
medicine.medical_specialty
Hydrocortisone
medicine.medical_treatment
Urology
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Mass Spectrometry
Article
Steroid
Veins
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Primary aldosteronism
Corticosterone
Cosyntropin
Adrenal Glands
Hyperaldosteronism
Internal Medicine
medicine
Humans
Aldosterone
Aged
Adrenal gland
business.industry
Middle Aged
medicine.disease
Subtyping
Peripheral
medicine.anatomical_structure
chemistry
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 15244563
- Volume :
- 75
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Hypertension (Dallas, Tex. : 1979)
- Accession number :
- edsair.doi.dedup.....b735568c5197d61ae2629d2f291f952b