Model organoids provide new research opportunities for ductal pancreatic cancer

Authors :: David A. Tuveson
Lindsey A. Baker
Chang-Il Hwang
Hans Clevers
Sylvia F. Boj
Dannielle D. Engle
Hubrecht Institute for Developmental Biology and Stem Cell Research
Source :: Molecular & cellular oncology, vol 3, iss 1, Molecular & Cellular Oncology, 3(1). Taylor & Francis Group, Molecular and Cellular Oncology, 3(1). Taylor and Francis Ltd.
Publication Year :: 2016
Publisher :: eScholarship, University of California, 2016.
Abstract: We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

ISSN :: 23723556
Database :: OpenAIRE
Journal :: Molecular & cellular oncology, vol 3, iss 1, Molecular & Cellular Oncology, 3(1). Taylor & Francis Group, Molecular and Cellular Oncology, 3(1). Taylor and Francis Ltd.
Accession number :: edsair.doi.dedup.....b72f7a211f000801c18207e65fe77c87

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