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Comparison of 208-week sequential therapy with telbivudine and entecavir in HBeAg-positive chronic hepatitis B patients with suboptimal responses to 24 weeks of Peg-IFNα-2a therapy: An open-labelled, randomized, controlled, 'real-life' trial
- Source :
- Journal of Viral Hepatitis. 24:36-42
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- The purpose of the study was to compare the efficacy and safety of 208-week sequential therapy with telbivudine and entecavir in HBeAg-positive chronic hepatitis B (CHB) patients with suboptimal responses to 24 weeks of Peg-IFNα-2a therapy. This was an open-label, randomized, controlled, "real-life" trial. HBeAg-positive CHB patients with serum HBV DNA ≥5.0 lg IU/mL and a
- Subjects :
- Adult
Male
0301 basic medicine
HBsAg
medicine.medical_specialty
Guanine
Alpha interferon
Gastroenterology
Polyethylene Glycols
03 medical and health sciences
Hepatitis B, Chronic
0302 clinical medicine
Liver Function Tests
Virology
Internal medicine
Telbivudine
medicine
Adefovir
Humans
Hepatitis B e Antigens
Seroconversion
Proportional Hazards Models
Hepatology
business.industry
Interferon-alpha
virus diseases
Entecavir
Viral Load
Recombinant Proteins
digestive system diseases
Treatment Outcome
030104 developmental biology
Infectious Diseases
HBeAg
DNA, Viral
Immunology
Female
030211 gastroenterology & hepatology
business
Viral load
Thymidine
medicine.drug
Subjects
Details
- ISSN :
- 13520504
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Viral Hepatitis
- Accession number :
- edsair.doi.dedup.....b72b13587e19ce369fa9b3985a0e885b
- Full Text :
- https://doi.org/10.1111/jvh.12790