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Strong down-regulation of glycophorin genes: A host defense mechanism against rotavirus infection
- Source :
- Infection, Genetics and Evolution. 44:403-411
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The mechanisms of rotavirus (RV) infection have been analyzed from different angles but the way in which RV modifies the transcriptome of the host is still unknown. Whole transcriptome shotgun sequencing of peripheral blood samples was used to reveal patterns of expression from the genome of RV-infected patients. RV provokes global changes in the transcriptome of infected cells, involving an over-expression of genes involved in cell cycle and chromatin condensation. While interferon IFI27 was hyper-activated, interferon type II was not suggesting that RV has developed mechanisms to evade the innate response by host cells after virus infection. Most interesting was the inhibition of genes of the glycophorins A and B (GYPA/B) family, which are the major sialoglycoproteins of the human erythrocyte membrane and receptor of several viruses for host invasion. RV infection induces a complex and global response in the host. The strong inhibition of glycophorins suggests a novel defense mechanism of the host to prevent viral infection, inhibiting the expression of receptors used by the virus for infection. The present results add further support to the systemic nature of RV infection.
- Subjects :
- Male
Rotavirus
0301 basic medicine
Microbiology (medical)
Host Defense Mechanism
Down-Regulation
RNA-Seq
Biology
medicine.disease_cause
Microbiology
Rotavirus Infections
Virus
Transcriptome
03 medical and health sciences
Interferon
Genetics
medicine
Cluster Analysis
Humans
Glycophorin
Gene Regulatory Networks
Glycophorins
Molecular Biology
Gene
Ecology, Evolution, Behavior and Systematics
Disease Resistance
030102 biochemistry & molecular biology
Gene Expression Profiling
High-Throughput Nucleotide Sequencing
Infant
Virology
030104 developmental biology
Infectious Diseases
Gene Expression Regulation
Case-Control Studies
Child, Preschool
Multigene Family
Host-Pathogen Interactions
biology.protein
Female
medicine.drug
Subjects
Details
- ISSN :
- 15671348
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Infection, Genetics and Evolution
- Accession number :
- edsair.doi.dedup.....b727be03f50b50f6d5d3c436cbf34f6f