ADRENOCORTICOTROPIN HORMONE AND CORTISOL DYNAMIC VARIATION IN CASE OF CHILDREN›S NEUROINFECTIONS

The data presented in the article deal with research of hormone changes in hypophysial-paranephric system in the course of neuroinfections. The given work was carried out with the purpose of detection of dependence of the cortisol and adrenocorticotropin hormone level on aetiology, gender, severity and period (cycle) of the disease.A comprehensive clinical and laboratorial checkup of 109 children with different nosological forms of neuroinfections was carried out: meningitis: viral, enteroviral, purulent and cerebromeningitis. Control board group was composed of 10 healthy children of the identical age. All the patients underwent the Adrenocorticotropin Hormone and Cortisol blood serum level, IFA technique being used, during acuity and reconvalesence. It has been determined that in case of neuroinfections irrrespective of the ethiology, hypophysis trophic funtction undergoes arrest during the whole disease period. While studying adrenal gland functioning during the acuity the increased cortisol secretion is observed, the degree of which is authentically higher in case of purulent meningitis and meningoencephalitis compared to hydromeningitis. On recovery the cortisol values decrease to healthy children’s level. A reliable dependence of the ACTH and cortisol level on the severity degree in case of purulent meningitis and meningoencephalitis was discovered ( brought to light). It is also satisfactorily brought to light that ACTH and cortisol levels depend on the severity degree in case of purulent meningitis and meningoencephalitis. It is proved that adrenal gland system function does not depend on the patients’ gender and age in case of neuroinfections.