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Relation of the Expression of Transcriptional Factor TFAP2B to That of Adipokines in Subcutaneous and Omental Adipose Tissues
- Source :
- Obesity. 18:1277-1282
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- To determine the potential role of the transcriptional factor-activating enhancer-binding protein-2beta (TFAP2B) in the regulation of expression of adipokines, adiponectin, leptin, and interleukin-6 (IL-6) in vivo, we quantified the mRNA expression levels of these adipokines and TFAP2B in visceral (omental) and abdominal subcutaneous adipose tissues of 66 individuals with variable degree of adiposity and studied their correlations with BMI and their plasma concentrations. We found that BMI correlated negatively with plasma adiponectin levels and positively with those of leptin. Adiponection mRNA expression in subcutaneous fat correlated negatively with BMI, whereas leptin mRNA levels in the omentum correlated with plasma leptin levels and BMI. In contrast, IL-6 mRNA levels in subcutaneous and omental fat did not correlate with BMI. IL-6 mRNA levels in the omental fat correlated with plasma IL-6 levels. Whereas TFAP2B mRNA expression did not correlate with BMI, it correlated negatively with adiponectin expression in the subcutaneous adipose tissue. Furthermore, TFAP2B mRNA expression correlated negatively with leptin and positively with IL-6 expression in both subcutaneous and omental adipose tissues. These relationships are consistent with our in vitro observations and indicate that TFAP2B seems to regulate the expression of various adipokines in vivo.
- Subjects :
- Leptin
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Abdominal Fat
Subcutaneous Fat
Medicine (miscellaneous)
Adipose tissue
Adipokine
Body Mass Index
Endocrinology
In vivo
Internal medicine
Blood plasma
medicine
Humans
RNA, Messenger
Interleukin 6
Aged
Aged, 80 and over
Metabolic Syndrome
Messenger RNA
Nutrition and Dietetics
biology
Adiponectin
Interleukin-6
Middle Aged
Diabetes Mellitus, Type 2
Transcription Factor AP-2
biology.protein
Female
Omentum
Subjects
Details
- ISSN :
- 19307381
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Obesity
- Accession number :
- edsair.doi.dedup.....b70bcc02f5aab7c23bb9e81e17c938e8