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Evolutionary history of carbon monoxide dehydrogenase/acetyl-CoA synthase, one of the oldest enzymatic complexes
- Source :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (6), pp.E1166-E1173. ⟨10.1073/pnas.1716667115⟩, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (6), pp.E1166-E1173. ⟨10.1073/pnas.1716667115⟩
- Publication Year :
- 2018
- Publisher :
- National Academy of Sciences, 2018.
-
Abstract
- Erratum in : Correction for Adam et al., Evolutionary history of carbon monoxide dehydrogenase/acetyl-CoA synthase, one of the oldest enzymatic complexes. [Proc Natl Acad Sci U S A. 2018]; International audience; Carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ ACS) is a five-subunit enzyme complex responsible for the carbonyl branch of the Wood-Ljungdahl (WL) pathway, considered one of the most ancient metabolisms for anaerobic carbon fixation, but its origin and evolutionary history have been unclear. While traditionally associated with methanogens and acetogens, the presence of CODH/ACS homologs has been reported in a large number of un-cultured anaerobic lineages. Here, we have carried out an exhaustive phylogenomic study of CODH/ACS in over 6,400 archaeal and bacterial genomes. The identification of complete and likely functional CODH/ACS complexes in these genomes significantly expands its distribution in microbial lineages. The CODH/ACS complex displays astounding conservation and vertical inheritance over geological times. Rare intradomain and interdomain transfer events might tie into important functional transitions, including the acquisition of CODH/ACS in some archaeal methanogens not known to fix carbon, the tinkering of the complex in a clade of model bacterial acetogens, or emergence of archaeal-bacterial hybrid complexes. Once these transfers were clearly identified, our results allowed us to infer the presence of a CODH/ACS complex with at least four subunits in the last universal common ancestor (LUCA). Different scenarios on the possible role of ancestral CODH/ACS are discussed. Despite common assumptions, all are equally compatible with an autotrophic, mixotrophic, or heterotrophic LUCA. Functional characterization of CODH/ACS from a larger spectrum of bacterial and archaeal lineages and detailed evolutionary analysis of the WL methyl branch will help resolve this issue.
- Subjects :
- 0301 basic medicine
Enzyme complex
MESH: Genome, Archaeal
LUCA
[SDV]Life Sciences [q-bio]
MESH: Genome, Bacterial
Genome
Corrections
chemistry.chemical_compound
Genome, Archaeal
MESH: Multienzyme Complexes/genetics
methanogens
Phylogeny
MESH: Phylogeny
Genetics
Carbon Monoxide
Multidisciplinary
Last universal ancestor
Carbon fixation
Acetyl-CoA
MESH: Carbon Cycle
Aldehyde Oxidoreductases
Biological Evolution
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
PNAS Plus
MESH: Bacteria/enzymology
Wood–Ljungdahl pathway
Wood-Ljungdahl pathway
MESH: Aldehyde Oxidoreductases/metabolism
Carbon monoxide dehydrogenase
030106 microbiology
MESH: Bacteria/genetics
Acetate-CoA Ligase
Bacterial genome size
Biology
MESH: Biological Evolution
MESH: Aldehyde Oxidoreductases/genetics
Carbon Cycle
03 medical and health sciences
MESH: Carbon Monoxide/metabolism
Multienzyme Complexes
MESH: Archaea/genetics
evolution
MESH: Acetate-CoA Ligase/metabolism
MESH: Multienzyme Complexes/metabolism
MESH: Archaea/enzymology
Bacteria
MESH: Acetate-CoA Ligase/genetics
Archaea
acetogens
030104 developmental biology
chemistry
biology.protein
Genome, Bacterial
Subjects
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (6), pp.E1166-E1173. ⟨10.1073/pnas.1716667115⟩, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (6), pp.E1166-E1173. ⟨10.1073/pnas.1716667115⟩
- Accession number :
- edsair.doi.dedup.....b70740951cefcc620e48a39d1e9e1153