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ADAMTS13 activity decreases in the early phase of trauma associated with coagulopathy and systemic inflammation: a prospective observational study
- Source :
- Thrombosis Journal, Thrombosis Journal, Vol 19, Iss 1, Pp 1-8 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background We conducted a prospective observational study for investigating the changes in the 13th member of a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS13) and its association with the coagulofibrinolytic response in adult trauma patients. Methods In 39 trauma patients hospitalized for longer than 7 days, time-course changes in biomarkers of coagulofibrinolysis and systemic inflammation along with ADAMTS13 activity were examined. The patients were stratified into three groups based on ADAMTS13 activities on admission (day 0): normal group (≥70%), mildly decreased group (≥50 and Results Among 39 patients with a median Injury Severity Score (ISS) of 20, 11 patients developed disseminated intravascular coagulation (DIC) and 16 patients required transfusion. Six of 39 patients (15.4%) showed moderate decreased ADAMTS13 activity to r = 0.513, p r = 0.647, p OR 7.499, 95%CI 1.121–49.242, p = 0.038) and the need for transfusion of fresh frozen plasma (OR 9.000, 95%CI 1.327–61.025, p = 0.028). Conclusions ADAMTS13 activity decreased even in the early phase of trauma, which was complicated by coagulopathy and systemic inflammation. Furthermore, the decrease in ADAMTS13 activity was correlated with DIC and plasma transfusion.
- Subjects :
- Coagulofibrinolysis
medicine.medical_specialty
Antithrombin
030204 cardiovascular system & hematology
Systemic inflammation
Gastroenterology
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Internal medicine
Coagulopathy
Medicine
030304 developmental biology
Fibrinogen degradation product
Disseminated intravascular coagulation
Prothrombin time
0303 health sciences
medicine.diagnostic_test
lcsh:RC633-647.5
business.industry
Research
Albumin
lcsh:Diseases of the blood and blood-forming organs
Hematology
medicine.disease
Extravascular leakage
Injury Severity Score
Fresh frozen plasma
medicine.symptom
Disseminated intravascular coagulation (DIC)
business
medicine.drug
Subjects
Details
- ISSN :
- 14779560
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Thrombosis Journal
- Accession number :
- edsair.doi.dedup.....b6f5da1bf0b47a518447bf5003d95c28