Back to Search Start Over

Protein C Pathway in Paediatric and Neonatal Sepsis

Protein C Pathway in Paediatric and Neonatal Sepsis

Authors :
Hassan Eliwan
Murwan Omer
Ellen McKenna
Lynne A. Kelly
Beatrice Nolan
Irene Regan
Eleanor J. Molloy
Source :
Frontiers in Pediatrics, Vol 9 (2022)
Publication Year :
2022
Publisher :
Frontiers Media SA, 2022.

Abstract

Protein C plays a major role in the physiological regulation of coagulation pathways through inactivation of factor Va, factor VIIIa, and plasminogen activator inhibitor. Protein C is involved in the control of inflammation during sepsis, by inhibiting release of pro-inflammatory cytokines, thereby controlling neutrophil, and monocyte effects on injured tissue. Recombinant human activated protein C (rhAPC) reduced mortality in adult sepsis in earlier studies but had no significant benefit in more recent trials. Protein C levels are reduced during paediatric and neonatal sepsis, which may play a major role in the development of disseminated intravascular thrombosis, purpura fulminans, and multiorgan dysfunction. The role of protein C in paediatric sepsis requires further clinical and immunological evaluation to define the patient subgroups who may benefit from this therapy. Newer versions of rhAPC are under development with less risk of haemorrhage potentially broadening the scope of this intervention.

Details

Language :
English
ISSN :
22962360
Volume :
9
Database :
OpenAIRE
Journal :
Frontiers in Pediatrics
Accession number :
edsair.doi.dedup.....b6f2374746d8fb9b5befdb6c339aec2d
Full Text :
https://doi.org/10.3389/fped.2021.562495