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Single cell analysis of the inner ear sensory organs
- Source :
- The International journal of developmental biology
- Publication Year :
- 2017
-
Abstract
- The inner ear is composed of a complex mixture of cells, which together allow organisms to hear and maintain balance. The cells in the inner ear, which undergo an extraordinary process of development, have only recently begun to be studied on an individual level. As it has recently become clear that individual cells, previously considered to be of uniform character, may differ dramatically from each other, the need to study cell-to-cell variation, along with distinct transcriptional and regulatory signatures, has taken hold in the scientific community. In conjunction with high-throughput technologies, attempts are underway to dissect the inter- and intra-cellular variability of different cell types and developmental states of the inner ear from a novel perspective. Single cell analysis of the inner ear sensory organs holds the promise of providing a significant boost in building an omics network that translates into a comprehensive understanding of the mechanisms of hearing and balance. These networks may uncover critical elements for trans-differentiation, regeneration and/or reprogramming, providing entry points for therapeutics of deafness and vestibular pathologies.
- Subjects :
- 0301 basic medicine
Embryology
Cell type
mice
Transcription, Genetic
cochlea
Sensory system
Biology
Article
03 medical and health sciences
Single-cell analysis
deafness
vestibule
medicine
otorhinolaryngologic diseases
Animals
Humans
Regeneration
Inner ear
Process (anatomy)
Vestibular system
Genome
Regeneration (biology)
Gene Expression Profiling
Stem Cells
Gene Expression Regulation, Developmental
Cell Differentiation
Anatomy
030104 developmental biology
medicine.anatomical_structure
Microscopy, Fluorescence
hearing
Ear, Inner
sense organs
Single-Cell Analysis
Transcriptome
Neuroscience
Reprogramming
Developmental Biology
Signal Transduction
Subjects
Details
- ISSN :
- 16963547
- Volume :
- 61
- Issue :
- 3-4-5
- Database :
- OpenAIRE
- Journal :
- The International journal of developmental biology
- Accession number :
- edsair.doi.dedup.....b6ede0289f4052cc11406896d9e88fd0