Back to Search
Start Over
Actions of progesterone and its 5α-reduced metabolites on the major proteins of the myelin of the peripheral nervous system
- Source :
- Steroids. 68:825-829
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- The sciatic nerve, and the Schwann cells in particular, are able to synthesize progesterone and possess the enzymes forming the 5alpha-reduced and the 3alpha-5alpha-reduced derivatives of progesterone: dihydroprogesterone and tetrahydroprogesterone. Moreover, the progesterone receptor (PR) is present in the sciatic nerve and in Schwann cell cultures. These facts suggest that progesterone and its derivatives might play a role in the control of the synthesis of the two major proteins of the peripheral nervous system (PNS): the glycoprotein Po (Po) and peripheral myelin protein 22 (PMP22). We have shown that: (a) dihydroprogesterone enhances the low mRNA levels of Po in the sciatic nerve of aged male rats; (b) progesterone and its derivatives stimulate the gene expression of Po in the sciatic nerve of adult rats and in Schwann cell cultures; (c) tetrahydroprogesterone increases PMP22 gene expression in the sciatic nerve of adult rats and in Schwann cell cultures. In additional experiments, utilizing agonists and antagonists of PR and GABAA receptor, we have observed that progesterone and its derivatives control Po gene expression via the PR, while tetrahydroprogesterone modulates the expression of PMP22 through the GABAA receptor.
- Subjects :
- Male
medicine.medical_specialty
Clinical Biochemistry
Schwann cell
Biology
Biochemistry
Myelin
Endocrinology
Internal medicine
Peripheral myelin protein 22
Peripheral Nervous System
Progesterone receptor
medicine
Animals
RNA, Messenger
Molecular Biology
Cells, Cultured
Myelin Sheath
Progesterone
Pharmacology
Organic Chemistry
Sciatic Nerve
Rats
medicine.anatomical_structure
nervous system
Dihydroprogesterone
Peripheral nervous system
Neuroglia
Schwann Cells
Sciatic nerve
Receptors, Progesterone
Myelin P0 Protein
Myelin Proteins
Subjects
Details
- ISSN :
- 0039128X
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Steroids
- Accession number :
- edsair.doi.dedup.....b6dcbfb85e0164042d567b7a35e80b5a