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Evaluation of lymph node metastases: Comparison of gadofluorine M-enhanced MRI and diffusion-weighted MRI in a rabbit VX2 rectal cancer model
- Source :
- Journal of Magnetic Resonance Imaging. 35:1179-1186
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Purpose: To compare the diagnostic performance of a diffusion-weighted imaging (DWI) dataset and a gadofluorine M-enhanced imaging dataset for identifying lymph node (LN) metastases in a rabbit rectal cancer model. Materials and Methods: VX2 carcinomas were injected into the rectum of 26 rabbits. Four weeks later, T2-weighted imaging (T2WI), pre-T1WI, DWI, and post-T1WI were performed. Two radiologists independently reviewed the DWI set (T2WI, pre-T1WI, DWI) and the gadofluorine M set (T2WI, pre- and post-T1WI) and recorded their confidence scores for LN metastasis on a per-LN basis. Receiver operating characteristic (ROC) analysis was performed to compare the area under the ROC curve (Az) of the two imaging sets. Histopathologic results were used as the reference standard. Results: The Az and sensitivity of the gadofluorine M set were comparable to those of the DWI set (Az, for reader 1, 0.849, 0.829, P = 0.571; for reader 2, 0.923, 0.876, P = 0.212; sensitivity, for reader 1, 97%, 97%; for reader 2, 97%, 92%, P = 0.304). The specificity of the former was greater than that of the latter (for reader 1, 65%, 53%, P = 0.0003; for reader 2, 81%, 68%, P = 0.01). Conclusion: Gadofluorine M-enhanced images provided greater specificity than DWI for identifying LN metastases, whereas the Az and sensitivity of the former were comparable to those of the latter. J. Magn. Reson. Imaging 2012;35:1179-1186. © 2012 Wiley Periodicals, Inc.
- Subjects :
- Colorectal cancer
Contrast Media
Rectum
Sensitivity and Specificity
Metastasis
Cell Line, Tumor
Organometallic Compounds
medicine
Animals
Effective diffusion coefficient
Radiology, Nuclear Medicine and imaging
Lymph node
Fluorocarbons
Receiver operating characteristic
Rectal Neoplasms
business.industry
Gadofluorine M
Neoplasms, Experimental
Image Enhancement
medicine.disease
Magnetic Resonance Imaging
Disease Models, Animal
Diffusion Magnetic Resonance Imaging
medicine.anatomical_structure
ROC Curve
Lymphatic Metastasis
Rabbits
business
Nuclear medicine
Neoplasm Transplantation
Diffusion MRI
Subjects
Details
- ISSN :
- 10531807
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Journal of Magnetic Resonance Imaging
- Accession number :
- edsair.doi.dedup.....b6db4dbee74cebe526eff39faaf22df9