Thrombopoietin receptor activation, thrombopoietin mimetic drugs, and hereditary thrombocytosis: remarks on bone marrow fibrosis

Thus,romiplostim administration mimics the increased stimulation byTpo, while chronic eltrombopag administration reminds the consti-tutive activation of MPL. Given that these drugs have to be lifelongadministered, concern emerged when it was noticed that some pa-tients with immune thrombocytopenia (ITP) receiving romiplostindeveloped bone marrow fibrosis.