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Interleukin-1β (IL-1β) increases pain behavior and the blood glucose level: Possible involvement of glucocorticoid system
- Source :
- Cytokine. 64:351-356
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- The possible involvement of glucocorticoid system in interleukin-1β (IL-1β)-induced nociception and the blood glucose level was studied in ICR mice. In the first experiment, mice were treated intrathecally (i.t.) with IL-1β (100 pg). Corticotrophin releasing hormone (CRH) mRNA (hypothalamus) and c-Fos mRNA (pituitary gland, spinal cord, and the adrenal gland) levels were measured at 30, 60 and 120 min after IL-1β administration. We found that i.t. injection with IL-1β increased CRH mRNA level in the hypothalamus. The IL-1β administered i.t. elevated c-Fos mRNA levels in the spinal cord, pituitary and adrenal glands. Furthermore, i.t. administration of IL-1β significantly increased the plasma corticosterone level up to 60 min. In addition, the adrenalectomy caused the reductions of the blood glucose level and pain behavior induced by IL-1β injected i.t. in normal and D -glucose-fed groups. Furthermore, intraperitoneal (i.p.) pretreatment with RU486 (100 mg/kg) attenuated the blood glucose level and pain behavior induced by IL-1β administered i.t. in normal and D -glucose-fed groups. Our results suggest that IL-1β administered i.t. increases the blood glucose level and pain behavior via an activation of the glucocorticoid system.
- Subjects :
- Blood Glucose
Male
Nociception
medicine.medical_specialty
Pituitary gland
Corticotropin-Releasing Hormone
medicine.medical_treatment
Interleukin-1beta
Immunology
Pain
Biochemistry
Mice
Hormone Antagonists
Receptors, Glucocorticoid
Internal medicine
Adrenal Glands
medicine
Animals
Immunology and Allergy
RNA, Messenger
Molecular Biology
Mice, Inbred ICR
Adrenal gland
business.industry
Adrenalectomy
Hematology
Spinal cord
Mifepristone
Glucose
medicine.anatomical_structure
Endocrinology
Spinal Cord
Hypothalamus
Pituitary Gland
Corticosterone
business
Proto-Oncogene Proteins c-fos
Glucocorticoid
Hormone
medicine.drug
Subjects
Details
- ISSN :
- 10434666
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Cytokine
- Accession number :
- edsair.doi.dedup.....b6cb9c7d71b79916e6aa795070c486c2