Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair

Made available in DSpace on 2021-06-25T15:07:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01. Added 1 bitstream(s) on 2021-07-15T15:06:29Z : No. of bitstreams: 1 S0102-86502021000400204.pdf: 2022697 bytes, checksum: 46b5efc0eb2de60a7b74b81cd435bb2e (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Purpose: The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. Methods: Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Lesion and AE (LE) and Lesion and FS associated to AE (LSE). The edema volume (EV), collagen ratio, and histopathological analysis were evaluated after 7, 14, and 21 days of partial tendon transection. Results: The EV was statistically reduced for all treatment groups after 7 and 21 days when compared to L group. The LS and LSE had the highest EV reduction after 21 days of treatment. The FS group didn't induce tissue necrosis or infections on the histopathological analysis. It was observed tenocytes proliferation, granulation tissue and collagen formation in the tendon partial transection area in the FS group. The LSE demonstrated higher amount of granulation tissue and increased the collagen deposition at the injury site. Conclusions: Our data suggests that the therapeutic potential of the association of heterologous fibrin biopolymer sealant with aquatic exercise program should be further explored as it may stimulate the regeneration phase and optimize calcaneal tendon recovery. Univ Brasil, Sci & Technol Inst, Sao Paulo, SP, Brazil Univ Estadual Piaui, Ctr Res Biotechnol & Biodivers, Teresina, PI, Brazil Univ Estadual Paulista, Ctr Study Venoms & Venomous Anim, Botucatu, SP, Brazil Univ Estadual Paulista, Botucatu Med Sch, Botucatu, SP, Brazil Univ Estadual Paulista, Ctr Study Venoms & Venomous Anim, Botucatu, SP, Brazil Univ Estadual Paulista, Botucatu Med Sch, Botucatu, SP, Brazil FAPESP: 2017/21851-0 CNPq: 303224/20185