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Network topology changes in chronic mild traumatic brain injury (mTBI)
- Source :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 31, Iss, Pp 102691-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Highlights • Brain networks in mTBI remain plastic decades after injury. • Global integration increased over time in mTBI group to the level of Controls. • mTBI networks became more clustered and less segregated into modules over time.<br />Background In mild traumatic brain injury (mTBI), diffuse axonal injury results in disruption of functional networks in the brain and is thought to be a major contributor to cognitive dysfunction even years after trauma. Objective Few studies have assessed longitudinal changes in network topology in chronic mTBI. We utilized a graph theoretical approach to investigate alterations in global network topology based on resting-state functional connectivity in veterans with chronic mTBI. Methods 50 veterans with chronic mTBI (mean of 20.7 yrs. from trauma) and 40 age-matched controls underwent two functional magnetic resonance imaging scans 18 months apart. Graph theory analysis was used to quantify network topology measures (density, clustering coefficient, global efficiency, and modularity). Hierarchical linear mixed models were used to examine longitudinal change in network topology. Results With all network measures, we found a significant group × time interaction. At baseline, brain networks of individuals with mTBI were less clustered (p = 0.03) and more modular (p = 0.02) than those of HC. Over time, the mTBI networks became more densely connected (p = 0.002), with increased clustering (p = 0.001) and reduced modularity (p
- Subjects :
- medicine.medical_specialty
Traumatic brain injury
Cognitive Neuroscience
Computer applications to medicine. Medical informatics
R858-859.7
Network topology
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
TBI
medicine
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
RC346-429
Brain Concussion
Clustering coefficient
Modularity (networks)
Brain Mapping
medicine.diagnostic_test
business.industry
Functional connectivity
05 social sciences
Diffuse axonal injury
fMRI
Brain
Infant
Cognition
Regular Article
medicine.disease
Magnetic Resonance Imaging
Graph theory
Neurology
Brain Injuries
Neurology (clinical)
Neurology. Diseases of the nervous system
business
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 22131582
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- NeuroImage : Clinical
- Accession number :
- edsair.doi.dedup.....b6c3d521bddc5d62430568244988c879