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Amphiphilic fluorescent probe self-encored in plasma to detect pH fluctuations in cancer cell membranes
- Source :
- Chemical Communications. 57:607-610
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- We have developed an amphiphilic pH probe (P1CS) to detect pH levels in the plasma membrane in cancer cells. An elevated fluorescence signal at 550 nm at the cell surface of cancer cells (MDA-MB-231, HeLa cells) prompted the application of P1CS as a pH marker for the cancer cell surface, discriminating it from normal cells (WI-38). Moreover, the probe enables labeling of the surface of multilayered tumor spheroids, which promotes its use as a marker for the surface of tumor tissue.
- Subjects :
- Cell
Tumor spheroid
Fluorescence
Catalysis
Cell Line
HeLa
Surface-Active Agents
Neoplasms
Amphiphile
Materials Chemistry
medicine
Humans
Fluorescent Dyes
Molecular Structure
biology
Chemistry
Cell Membrane
Metals and Alloys
General Chemistry
Plasma
Hydrogen-Ion Concentration
biology.organism_classification
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Membrane
medicine.anatomical_structure
Cancer cell
Ceramics and Composites
Biophysics
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....b6b147b54345eeb54a907288f6c2cdda
- Full Text :
- https://doi.org/10.1039/d0cc06694j