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Amphiphilic fluorescent probe self-encored in plasma to detect pH fluctuations in cancer cell membranes

Authors :
Sankarprasad Bhuniya
Kaustabh Kumar Maiti
Sanjib Samanta
Manu M. Joseph
Arup Podder
Shayeri Biswas
Source :
Chemical Communications. 57:607-610
Publication Year :
2021
Publisher :
Royal Society of Chemistry (RSC), 2021.

Abstract

We have developed an amphiphilic pH probe (P1CS) to detect pH levels in the plasma membrane in cancer cells. An elevated fluorescence signal at 550 nm at the cell surface of cancer cells (MDA-MB-231, HeLa cells) prompted the application of P1CS as a pH marker for the cancer cell surface, discriminating it from normal cells (WI-38). Moreover, the probe enables labeling of the surface of multilayered tumor spheroids, which promotes its use as a marker for the surface of tumor tissue.

Details

ISSN :
1364548X and 13597345
Volume :
57
Database :
OpenAIRE
Journal :
Chemical Communications
Accession number :
edsair.doi.dedup.....b6b147b54345eeb54a907288f6c2cdda
Full Text :
https://doi.org/10.1039/d0cc06694j