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Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study
- Source :
- Journal of Alzheimer's disease 82(2), 827-839 (2021). doi:10.3233/JAD-201238
- Publication Year :
- 2021
-
Abstract
- Background: Adherence to the Mediterranean-DASH for Neurodegenerative Delay (MIND) diet has previously been associated with cognitive decline and dementia. To our knowledge, no prior study has investigated the association between the MIND diet and measures of brain volume, silent brain infarcts (SBIs), or brain atrophy. Objective: We evaluated whether adherence to the MIND diet associated with superior cognitive function, larger brain volumes, fewer SBIs, and less cognitive decline in the community-based Framingham Heart Study. Methods: 2,092 participants (mean±SD, age 61±9) completed Food Frequency Questionnaires, averaged across a maximum of 3-time points (examination cycles 5, 6, and 7), cognitive testing at examination cycle 7 (present study baseline: 1998–2001) and after a mean±SD of 6.6±1.1 years from baseline (n = 1,584). A subset of participants also completed brain magnetic resonance imaging (MRI) at examination cycle 7 (n = 1,904). In addition, participants with dementia, stroke, and other relevant neurological diseases such as significant head trauma, subdural hematoma, or multiple sclerosis were excluded from the analyses. Results: Higher MIND diet scores were associated with better global cognitive function (β±SE,+0.03SD±0.01; p = 0.004), verbal memory, visual memory, processing speed, verbal comprehension/reasoning, and with larger total brain volume (TBV) following adjustments for clinical, lifestyle and demographic covariates, but not with other brain MRI measures (i.e., hippocampal volume, lateral ventricular volume, white matter hyperintensity volume, and SBIs) or cognitive decline. Conclusion: Higher MIND diet scores associated with better cognitive performance and larger TBV at baseline, but not with cognitive decline. Clinical trials are needed to ascertain whether adopting the MIND diet affects trajectories of cognitive decline.
- Subjects :
- cognition
Male
epidemiology [Cognitive Dysfunction]
brain volume
Neuropsychological Tests
Diet, Mediterranean
0302 clinical medicine
Framingham Heart Study
methods [Magnetic Resonance Imaging]
Cognition
pathology [Brain]
030212 general & internal medicine
epidemiology [Brain Infarction]
Longitudinal Studies
Cognitive decline
statistics & numerical data [Diet, Mediterranean]
psychology [Diet, Mediterranean]
statistics & numerical data [Patient Compliance]
General Neuroscience
physiology [Cognition]
Brain
General Medicine
Organ Size
Middle Aged
Magnetic Resonance Imaging
Cognitive test
silent brain infarcts
Psychiatry and Mental health
Clinical Psychology
Treatment Outcome
prevention & control [Cognitive Dysfunction]
Female
dietary pattern
Brain Infarction
medicine.medical_specialty
Apolipoprotein ɛ4
03 medical and health sciences
Physical medicine and rehabilitation
Visual memory
framingham heart study
medicine
Dementia
Humans
Cognitive Dysfunction
Effects of sleep deprivation on cognitive performance
ddc:610
diagnostic imaging [Brain]
Aged
business.industry
medicine.disease
psychology [Patient Compliance]
Asymptomatic Diseases
Patient Compliance
MIND diet
Geriatrics and Gerontology
Verbal memory
business
diagnosis [Brain Infarction]
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 82
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....b6acacb0ab32d730eb08811f330807d4