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Communicating hydrocephalus. Cisternographic and neuropathologic studies
- Source :
- Archives of neurology. 33(1)
- Publication Year :
- 1976
-
Abstract
- Chronic communicating hydrocephalus was produced in adult dogs by injection of silastic into the subarachnoid space. Electron microscopy was used to verify the sequence of pathologic changes in the ventricular wall. The pathologic findings were correlated with cisternographic images and measurements of cerebrospinal fluid (CSF) pressure. Early in hydrocephalus, the CSF pressure was increased and cisternograms showed ventricular entry and clearing; the ependyma was stretched and fluid accumulated in subependymal regions. In animals with chronic hydrocephalus, the CSF pressure was normal and cisternograms disclosed radioactivity persisting in the ventricles. At this time the ependyma was severely damaged, the subependymal white matter showed enlargement of the extracellular space, and degenerative changes were present in axons and myelin sheaths.
- Subjects :
- Pathology
medicine.medical_specialty
business.industry
Central nervous system
medicine.disease
Hydrocephalus
Cerebral Ventricles
White matter
Microscopy, Electron
medicine.anatomical_structure
Cerebrospinal fluid
Dogs
Arts and Humanities (miscellaneous)
Cerebral ventricle
Chronic Disease
medicine
Subependymal zone
Silicone Elastomers
Animals
Neurology (clinical)
Subarachnoid space
Ependyma
business
Radionuclide Imaging
Subjects
Details
- ISSN :
- 00039942
- Volume :
- 33
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Archives of neurology
- Accession number :
- edsair.doi.dedup.....b6a91bb9209302b9f5746cf943699fb5