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Clinical characteristics, treatment and prognosis of angiocentric glioma
- Source :
- Oncology Letters
- Publication Year :
- 2020
- Publisher :
- Spandidos Publications, 2020.
-
Abstract
- Angiocentric glioma (AG) is a rare subtype of neuroepithelial tumor in children and young adults that commonly presents with seizures. To study the clinical characteristics, treatment and prognosis of patients with AG, the features of two cases of AG were described and 108 cases reported in the literature were assessed. The cases of the present study were two males aged 8 and 16 years, who mainly presented with seizures. MRI revealed superficial, non-enhanced lesions in the left temporal and right frontal lobe, respectively. The two patients underwent gross total resection (GTR) and remained seizure-free without neurological deficits after 3.5 and 2.5 years, respectively. Histopathological examination revealed that the tumors consisted of monomorphous cells that surrounded the blood vessels and neurons in the cerebral cortex, and formed concentric sleeves or pseudorosettes. Furthermore, immunostaining indicated that the diffuse infiltrative neoplastic cells were positive for glial fibrillary acidic protein and a dot-like pattern of epithelial membrane antigen was observed. AG mostly appeared similar to low-grade gliomas on MRI. GTR of the lesions was curative and radiation or chemotherapy were not required. AG typically has a favorable prognosis, with low mortality and incidence of disability.
- Subjects :
- 0301 basic medicine
Cancer Research
Pathology
medicine.medical_specialty
children/young adults
Angiocentric Glioma
medicine.medical_treatment
neuroepithelial tumor
pseudorosettes
angiocentric glioma
03 medical and health sciences
0302 clinical medicine
medicine
Young adult
Chemotherapy
low-grade glioma
Glial fibrillary acidic protein
biology
business.industry
Cancer
Articles
medicine.disease
Neuroepithelial cell
030104 developmental biology
medicine.anatomical_structure
Oncology
Cerebral cortex
030220 oncology & carcinogenesis
biology.protein
business
Immunostaining
Subjects
Details
- ISSN :
- 17921082 and 17921074
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....b6a6f2401dcd9742f97c0a4998be004a