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Clinicopathologic significance of ROCK2 expression in oral squamous cell carcinomas
- Source :
- Journal of Oral Pathology & Medicine. 47:121-127
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Background Rho-associated coiled-coil kinase 2 (ROCK2) is an oncoprotein that controls cytoskeleton organization and acts as prognostic marker in different types of solid tumors. ROCK2 overexpression is also observed in cancer-associated fibroblasts (CAF), which suggests its relevance within the tumor microenvironment. This study aimed to access the prognostic value of ROCK2 in oral squamous cell carcinomas (OSCC) and its association with CAF density. Methods ROCK2 immunohistochemical analysis was applied in 93 OSCC samples from 2 centers in Brazil and Finland. The samples were also stained for isoform α of smooth muscle actin (α-SMA) to characterize the presence of CAF in the tumor stroma. Clinicopathologic associations were analyzed using chi-square test, survival curves were constructed according to the Kaplan-Meier method, and Cox proportional hazard model was applied for multivariate survival analysis. Results Advanced clinical stage (p=0.002) and increased density of CAF (p=0.002) were significantly associated with high ROCK2 expression. The high expression of ROCK2 was also associated with shortened disease-specific survival (HR: 2.22, 95% CI: 1.15-4.38, p=0.04), but the association did not withstand the Cox multivariate survival analysis. Conclusions The findings suggest that high ROCK2 expression in OSCC is associated with advanced disease and follows the increase in CAF density, which may be important for tumor progression. This article is protected by copyright. All rights reserved.
- Subjects :
- Male
0301 basic medicine
Cancer Research
Pathology
Cytoskeleton organization
Kaplan-Meier Estimate
Metastasis
0302 clinical medicine
Cancer-Associated Fibroblasts
Risk Factors
Tumor Microenvironment
Finland
Aged, 80 and over
rho-Associated Kinases
Smoking
Middle Aged
Prognosis
Immunohistochemistry
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Periodontics
Female
Mouth Neoplasms
Oral Surgery
Brazil
Adult
medicine.medical_specialty
Alcohol Drinking
Biology
Pathology and Forensic Medicine
03 medical and health sciences
Biomarkers, Tumor
medicine
Humans
Survival analysis
Aged
Neoplasm Staging
Proportional Hazards Models
Tumor microenvironment
Proportional hazards model
Cancer
medicine.disease
Survival Analysis
Actins
030104 developmental biology
Otorhinolaryngology
Tumor progression
Multivariate Analysis
Cancer research
Subjects
Details
- ISSN :
- 09042512
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Journal of Oral Pathology & Medicine
- Accession number :
- edsair.doi.dedup.....b6a37b6ea832c663d23740e0db434d3b