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Frailty and restrictions in geriatric domains are associated with surgical complications but not with radiation-induced acute toxicity in head and neck cancer patients
- Source :
- Oral Oncology, 118:105329. ELSEVIER SCIENCE BV
- Publication Year :
- 2021
- Publisher :
- ELSEVIER SCIENCE BV, 2021.
-
Abstract
- OBJECTIVES: We aimed to evaluate the association between frailty screening and geriatric assessment (GA) on short term adverse events in patients treated for head and neck cancer (HNC) for the first time in a prospective study.MATERIALS AND METHODS: Newly diagnosed HNC patients undergoing curative treatment were prospectively included in OncoLifeS, a data biobank. Prior to the start of treatment, frailty was assessed with a GA, Groningen Frailty Indicator (GFI) and Geriatric-8 (G8). The GA included comorbidity (Adult Comorbidity Evaluation - 27), nutritional status (Malnutrition Universal Screening Tool), functional status ((instrumental) Activities of Daily Living), mobility (Timed Up & Go), psychological (Geriatric Depression Scale 15) and cognitive (Mini Mental State Examination) measures. Clinically relevant postoperative complications (Clavien-Dindo ≥ grade 2) and acute radiation-induced toxicity (Common Terminology Criteria for Adverse Events version 4.0 ≥ grade 2) were defined as outcome measures. Univariable and multivariable logistic regression analyses were performed, yielding odds ratios (ORs) and 95% confidence intervals (95%CIs).RESULTS: Of the 369 included patients, 259 patients were eligible for analysis. Postoperative complications occurred in 41/148 (27.7%) patients and acute radiation-induced toxicity was present in 86/160 (53.7%) patients. Number of deficit domains of GA (OR = 1.71, 95%CI = 1.14-2.56), GFI (OR = 2.54, 95%CI = 1.02-6.31) and G8 (OR5.59, 95%CI = 2.14-14.60) were associated with postoperative complications, but not with radiation-induced toxicity.CONCLUSION: Frailty and restrictions in geriatric domains were associated with postoperative complications, but not with radiation-induced acute toxicity in curatively treated HNC patients. The results of this prospective study further emphasizes the importance of geriatric evaluation, particularly before surgery.
- Subjects :
- Cancer Research
medicine.medical_specialty
VALIDATION
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
AGE
Internal medicine
Activities of Daily Living
Humans
Medicine
Radiation Injuries
030223 otorhinolaryngology
Prospective cohort study
Adverse effect
Geriatric Assessment
INDEX
Aged
OUTCOMES
Mini–Mental State Examination
medicine.diagnostic_test
Frailty
Radiotherapy
OLDER PATIENTS
business.industry
Head and neck cancer
Common Terminology Criteria for Adverse Events
Odds ratio
medicine.disease
Comorbidity
Logistic Models
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Geriatric Depression Scale
Oral Surgery
business
COMORBIDITY
Prospective studies
Subjects
Details
- Language :
- English
- ISSN :
- 13688375
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- Oral Oncology
- Accession number :
- edsair.doi.dedup.....b6976b5f3fe6495d587e457397a7e06c