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Fighting tubulin-targeting anticancer drug toxicity and resistance
- Source :
- Endocrine-related cancer 24 (2017): T107–T117. doi:10.1530/ERC-17-0120, info:cnr-pdr/source/autori:Visconti, Roberta; Grieco, Domenico/titolo:Fighting tubulin-targeting anticancer drug toxicity and resistance/doi:10.1530%2FERC-17-0120/rivista:Endocrine-related cancer/anno:2017/pagina_da:T107/pagina_a:T117/intervallo_pagine:T107–T117/volume:24
- Publication Year :
- 2017
- Publisher :
- BioScientifica, Bristol , Regno Unito, 2017.
-
Abstract
- Tubulin-targeting drugs, like taxanes and vinca alkaloids, are among the most effective anticancer therapeutics used in the clinic today. Specifically, anti-microtubule cancer drugs (AMCDs) have proven to be effective in the treatment of castration-resistant prostate cancer and triple-negative breast cancer. AMCDs, however, have limiting toxicities that include neutropenia and neurotoxicity, and, in addition, tumor cells can become resistant to the drugs after long-term use. Co-targeting mitotic progression/slippage with inhibition of the protein kinases WEE1 and MYT1 that regulate CDK1 kinase activity may improve AMCD efficacy, reducing the acquisition of resistance by the tumor and side effects from the drug and/or its vehicle. Other possible treatments that improve outcomes in the clinic for these two drug-resistant cancers, including new formulations of the AMCDs and pursuing different molecular targets, will be discussed.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
Vinca
Endocrinology, Diabetes and Metabolism
Cell Cycle Proteins
Triple Negative Breast Neoplasms
Pharmacology
taxane
vinca alkaloids
Prostate cancer
0302 clinical medicine
Endocrinology
Antineoplastic Combined Chemotherapy Protocols
Medicine
castration-resistant prostate cancer
Triple-negative breast cancer
media_common
biology
mitosi
Nuclear Proteins
Protein-Tyrosine Kinases
Tubulin Modulators
DNA-Binding Proteins
Wee1
Oncology
030220 oncology & carcinogenesis
triple-negative breast cancer
Drug
media_common.quotation_subject
spindle assembly checkpoint
03 medical and health sciences
Breast cancer
Animals
Humans
Protein Kinase Inhibitors
mitosis
Taxane
business.industry
MYT1
Neurotoxicity
Prostatic Neoplasms
biology.organism_classification
medicine.disease
030104 developmental biology
Drug Resistance, Neoplasm
biology.protein
WEE1 inhibitor
business
Transcription Factors
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Endocrine-related cancer 24 (2017): T107–T117. doi:10.1530/ERC-17-0120, info:cnr-pdr/source/autori:Visconti, Roberta; Grieco, Domenico/titolo:Fighting tubulin-targeting anticancer drug toxicity and resistance/doi:10.1530%2FERC-17-0120/rivista:Endocrine-related cancer/anno:2017/pagina_da:T107/pagina_a:T117/intervallo_pagine:T107–T117/volume:24
- Accession number :
- edsair.doi.dedup.....b693c4b6618d52258e1059344580af6d