D-Dimer, A Predictor Of Bad Outcome In Gastric Cancer Patients Undergoing Radical Resection

Introduction: As a marker of hypercoagulability, plasma D-dimer is associated with progression of many cancers but remains controversial in gastric cancer (GC). We aim to investigate the predictive value of D-dimer for postoperative outcomes after radical gastrectomy of GC patients.Materials and Methods: We enrolled 903 consecutive patients with GC who underwent radical gastrectomy and the clinicopathological characteristics were compared. Risk factors for overall survival (OS) and disease-free survival (DFS) were determined using multivariate cox regression analysis. We also compared the difference in survival between the two groups after a one-to-one propensity score matching (PSM).Results: Patients with elevated D-dimer had older age (pConclusion: Preoperative plasma D-dimer is an independent prognostic factor for GC patients undergoing curative gastrectomy.