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A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole
- Source :
- BMC Veterinary Research, Vol 8, Iss 1, p 210 (2012), BMC Veterinary Research
- Publication Year :
- 2012
- Publisher :
- BMC, 2012.
-
Abstract
- Background The poultry industry due to intensive methods of farming is burdened with losses from numerous infectious agents, of which one is the fungus Aspergillus fumigatus. In a preliminary study, the extracts of Loxostylis alata A. Spreng, ex Rchb. showed good activity in vitro against A. fumigatus with a minimum inhibitory concentration of 0.07 mg/ml. For this study crude, a crude acetone extract of L. alata leaves was evaluated for its acute toxicity in a healthy chicken model and for efficacy in an infectious model of aspergillosis (A. fumigatus). Results At a dose of 300 mg/kg, the extract induced some toxicity characterised by decreased feed intake and weight loss. Consequently, 100 and 200 mg/kg were used to ascertain efficacy in the infectious model. The plant extract significantly reduced clinical disease in comparison to the control in a dose dependant manner. The extract was as effective as the positive control ketoconazole dosed at 60 mg/kg. Conclusions The results indicate that a crude extract of L. alata leaves has potential as an antifungal agent to protect poultry against avian aspergillosis.
- Subjects :
- Veterinary medicine
Antifungal Agents
Anacardiaceae
Aspergillosis
Aspergillus fumigatus
Minimum inhibitory concentration
medicine
Animals
Loxostylis alata
Poultry Diseases
Aspergillus
lcsh:Veterinary medicine
General Veterinary
biology
Plant Extracts
General Medicine
biology.organism_classification
medicine.disease
veterinary(all)
Acute toxicity
Broiler chicks
Ketoconazole
Liver
Toxicity
lcsh:SF600-1100
Chemical and Drug Induced Liver Injury
Chickens
Research Article
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 17466148
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Veterinary Research
- Accession number :
- edsair.doi.dedup.....b671f7ed0970c82929c32d73e759f984