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Non-invasive diagnosis and follow-up of autoimmune hepatitis
- Source :
- Clinics and Research in Hepatology and Gastroenterology, Clinics and Research in Hepatology and Gastroenterology, 2022, 46 (1), ⟨10.1016/j.clinre.2021.101772⟩, Clinics and Research in Hepatology and Gastroenterology, 2022, 46 (1), pp.101772. ⟨10.1016/j.clinre.2021.101772⟩
- Publication Year :
- 2021
-
Abstract
- International audience; Autoimmune hepatitis (AIH) is a liver disease characterised by necrotico-inflammatory lesions of hepatocytes, the presence of specific autoantibodies and response to corticosteroid treatment. AIH must be considered in any patient with acute or chronic liver disease. As there is no pathognomonic sign of AIH, the diagnosis is based on a combination of clinical, biological, immunological and histological findings, after excluding other causes of liver disease. The clinical and biological presentation of AIH is variable and AIH can be associated with an autoimmune biliary disease, primary biliary cholangitis or primary sclerosing cholangitis in an overlap syndrome. For these reasons, diagnosis of AIH can be challenging. Even if liver histology remains essential in the diagnosis of AIH, non-invasive tests can be used at different steps of the management of AIH: diagnosis of AIH, notably diagnosis of an overlap syndrome, assessment of severity of AIH, searching for extra-hepatic disease frequently associated to AIH, evaluation of response to therapy, decision of treatment withdrawal. This review aims to provide practical guidelines for the use of non-invasive tests for the diagnosis and the follow-up of AIH. (C) 2021 Published by Elsevier Masson SAS.
- Subjects :
- medicine.medical_specialty
[SDV]Life Sciences [q-bio]
Cholangitis, Sclerosing
Disease
Autoimmune hepatitis
Chronic liver disease
overlap syndrome
Gastroenterology
Primary sclerosing cholangitis
Biliary disease
Liver disease
immune system diseases
Internal medicine
medicine
Humans
Hepatology
autoimmune hepatitis
business.industry
Liver Cirrhosis, Biliary
Autoantibody
Overlap syndrome
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
medicine.disease
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
digestive system diseases
[SDV] Life Sciences [q-bio]
Hepatitis, Autoimmune
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 2210741X and 22107401
- Volume :
- 46
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinics and research in hepatology and gastroenterology
- Accession number :
- edsair.doi.dedup.....b671211d562b184ff2811633f0a73824