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Serotonin transporter polymorphisms and early response to antipsychotic treatment in first episode of psychosis
- Source :
- Psychiatry Research. 175:189-194
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- article i nfo There is substantial evidence suggesting that individual variability in antipsychotic treatment response could be genetically determined. Variations in several serotonin transporter (5-HTT) gene polymorphisms have been associated with antipsychotic response among chronic patients with schizophrenia, although their implication in early response among first-episode patients remains unclear. Two polymorphisms in the 5- HTTgene (a 44 bp insertion/deletion in the promoter region and the functional polymorphism rs25531) were genotyped in a sample of 147 drug-naive patients experiencing a first episode of a non-affective psychosis. Early (6 weeks) response to antipsychotic treatment with haloperidol, olanzapine or risperidone was assessed with the Brief Psychiatric Rating Scale, the Scale for the Assessment of Positive Symptoms, and the Scale for the Assessment of Negative Symptoms. No clear association was found between the rs25531 variant and treatment response. However, significant associations were observed between 5-HTT-LPR variants and early negative symptom response among first-episode patients with psychosis. Our results suggest a minor contribution to antipsychotic drug response of genetic alterations in the 5-HTT gene.
- Subjects :
- Adult
Male
Olanzapine
Oncology
Psychosis
medicine.medical_specialty
Adolescent
Genotype
medicine.medical_treatment
Young Adult
Internal medicine
Brief Psychiatric Rating Scale
medicine
Humans
Longitudinal Studies
Promoter Regions, Genetic
Antipsychotic
Psychiatry
Scale for the Assessment of Negative Symptoms
Biological Psychiatry
Serotonin Plasma Membrane Transport Proteins
First episode
Chi-Square Distribution
Polymorphism, Genetic
Risperidone
Middle Aged
medicine.disease
Psychiatry and Mental health
Schizophrenia
Female
Psychology
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 01651781
- Volume :
- 175
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research
- Accession number :
- edsair.doi.dedup.....b66e9d2521cf3132e0540b0a05d8b893