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Central processing of leg proprioception in Drosophila
- Source :
- eLife, Vol 9 (2020), eLife
- Publication Year :
- 2020
- Publisher :
- eLife Sciences Publications Ltd, 2020.
-
Abstract
- Proprioception, the sense of self-movement and position, is mediated by mechanosensory neurons that detect diverse features of body kinematics. Although proprioceptive feedback is crucial for accurate motor control, little is known about how downstream circuits transform limb sensory information to guide motor output. Here we investigate neural circuits inDrosophilathat process proprioceptive information from the fly leg. We identify three cell types from distinct developmental lineages that are positioned to receive input from proprioceptor subtypes encoding tibia position, movement, and vibration. 13Bα neurons encode femur-tibia joint angle and mediate postural changes in tibia position. 9Aα neurons also drive changes in leg posture, but encode a combination of directional movement, high frequency vibration, and joint angle. Activating 10Bα neurons, which encode tibia vibration at specific joint angles, elicits pausing in walking flies. Altogether, our results reveal that central circuits integrate information across proprioceptor subtypes to construct complex sensorimotor representations that mediate diverse behaviors, including reflexive control of limb posture and detection of leg vibration.
- Subjects :
- musculoskeletal diseases
Sensory Receptor Cells
QH301-705.5
proprioception
Science
Sensory system
Kinematics
Biology
General Biochemistry, Genetics and Molecular Biology
Feedback, Sensory
Neural Pathways
Motor system
Biological neural network
motor control
Animals
Tibia
Biology (General)
Muscle, Skeletal
sensorimotor
D. melanogaster
General Immunology and Microbiology
Proprioception
behavior
General Neuroscience
Motor control
General Medicine
electrophysiology
Biomechanical Phenomena
Hindlimb
Electrophysiology
Drosophila melanogaster
Medicine
Neuroscience
Research Article
Subjects
Details
- Language :
- English
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....b66c60059ed3cb363a436cb3dd4529fa