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A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold
- Source :
- Chemical Communications. 58:645-648
- Publication Year :
- 2022
- Publisher :
- Royal Society of Chemistry (RSC), 2022.
-
Abstract
- Herein we report a thiol-labile cysteine protecting group based on an unsaturated pyridazinedione (PD) scaffold. We establish compatibility of the PD in conventional solid phase peptide synthesis (SPPS), showcasing this in the on-resin synthesis of biologically relevant oxytocin. Furthermore, we establish the applicability of the PD protecting group towards both microwave-assisted SPPS and native chemical ligation (NCL) in a model system.
- Subjects :
- chemistry.chemical_classification
Scaffold
010405 organic chemistry
Metals and Alloys
Model system
General Chemistry
010402 general chemistry
Native chemical ligation
01 natural sciences
Combinatorial chemistry
Catalysis
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
chemistry
Materials Chemistry
Ceramics and Composites
Peptide synthesis
Thiol
Protecting group
Solid-Phase Synthesis Techniques
Cysteine
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....b66a2c7f6a2f85eb38d4b4e4fc63e295