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A prospective clinical investigation of the effects of anti-TNF alpha therapy on exercise capacity in patients with ankylosing spondylitis
- Source :
- Volume: 49, Issue: 1 27-32, Turkish Journal of Medical Sciences
- Publication Year :
- 2019
- Publisher :
- The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS, 2019.
-
Abstract
- Background/aim The purpose of this study was to investigate possible effects of anti-TNF alpha therapy on cardiorespiratory fitness and physical functional capacity of patients with ankylosing spondylitis (AS). Materials and methods Twenty-eight AS patients meeting the modified New York criteria with active disease state and an equivalent number of healthy individuals as the control were prospectively enrolled. Physical working capacity and aerobic exercise capacity of the participants were determined by using cardiopulmonary exercise tests, performed before and 4 months after initiation of anti-TNF alpha therapy. Results The mean age of the patients was 37 ± 9.1 years, and mean duration of disease was 8.9 ± 7.6 years. Patients with AS exhibited significantly lower aerobic exercise capacity (VO2peak: 21.2 ± 5.5 vs. 27.2 ± 6.6 ml/kg/min, P = 0.001), maximum power output (110.4 ± 34.8 vs.153 ± 39.8 W, P = 0.0001), and exercise duration (16.3 ± 2.6 vs. 19.6 ± 2.9 min, P = 0.0001) than the healthy controls. When patients were reevaluated after 4 months of anti-TNF alpha therapy, significant improvement was obtained in patients’ aerobic capacity, maximum power output, and exercise duration. Conclusions Results from this study indicate that in addition to inflammatory parameters and quality of life index, even short-term anti-TNF alpha therapy results in significant improvement in cardiopulmonary health status as objectively reflected by peak VO2,maximum work rate, and exercise duration.
- Subjects :
- Adult
Male
Anti-Inflammatory Agents
Alpha (ethology)
030204 cardiovascular system & hematology
Work rate
Article
Anti-TNF-alpha therapy
03 medical and health sciences
0302 clinical medicine
physical functional capacity
medicine
Humans
Aerobic exercise
Spondylitis, Ankylosing
In patient
Prospective Studies
Aerobic capacity
0303 health sciences
Ankylosing spondylitis
Ankylosing spondylitis,anti-TNF alpha therapy,aerobic capacity,physical functional capacity
Tumor Necrosis Factor-alpha
030306 microbiology
business.industry
Cardiorespiratory fitness
General Medicine
Middle Aged
medicine.disease
anti-TNF alpha therapy
Respiratory Function Tests
aerobic capacity
Anesthesia
Exercise Test
Female
business
Subjects
Details
- ISSN :
- 13036165 and 13000144
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Accession number :
- edsair.doi.dedup.....b6656d9b4a5bcb2be29387635e230e93