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Overall survival after recurrence in stage I-III colorectal cancer patients in accordance with the recurrence organ site and pattern
- Source :
- Annals of Gastroenterological Surgery, Annals of Gastroenterological Surgery, Vol 5, Iss 6, Pp 813-822 (2021)
- Publication Year :
- 2021
-
Abstract
- Aim This study aimed to investigate the prognosis after recurrence in patients with stage I–III colon cancer (CC) and rectal cancer (RC). Methods Cancer recurred in 116 (15.2%) out of 763 patients with stage I–III colorectal cancer. The overall survival (OS) after recurrence was evaluated based on the recurrence organs and patterns. Results The first recurrence occurred in the lungs, livers, lymph nodes, and other sites in 32, 22, 12, and 2 patients, respectively. It was localized, disseminated, and involved two or more organs in 14, 9, and 25 patients, respectively. Patients with CC had a shorter OS after recurrence as compared to those with RC (P = .0103). Compared to other organ metastasis, liver metastasis was associated with an earlier recurrence (P = .0026) and shorter OS after recurrence (hazard ratio [HR]: 2.216; 95% confidence interval [CI]: 1.052–4.459; P = .0370). Lung metastasis was associated with a more favorable prognosis as compared to other organ recurrences (HR: 0.338; 95% CI: 0.135–0.741; P = .0057). One‐organ recurrence and oligometastasis were observed in 78.4% and 49.1% of the patients, respectively. The 5‐y OS rates of patients with one‐organ recurrence and oligometastasis were 47.5% and 71.7%, respectively. Invasive treatment was associated with a favorable prognosis (P<br />One organ recurrence was observed in 78.4% of patients and oligometastasis in 49.1%. The 5‐y OS rates of patients with one organ recurrence and oligometastasis were 47.5% and 71.7%, respectively. Invasive treatment was associated with a favorable prognosis (P
- Subjects :
- medicine.medical_specialty
RD1-811
Colorectal cancer
recurrence organ
colorectal cancer
RC799-869
Gastroenterology
Metastasis
Internal medicine
medicine
Overall survival
Stage (cooking)
business.industry
Hazard ratio
Cancer
Original Articles
recurrence pattern
Diseases of the digestive system. Gastroenterology
medicine.disease
Confidence interval
oligometastasis
Surgery
Original Article
Lymph
prognosis
business
Subjects
Details
- ISSN :
- 24750328
- Volume :
- 5
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Annals of gastroenterological surgery
- Accession number :
- edsair.doi.dedup.....b6615948de11c05b8bed2f3e5713dc12