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A Common Receptor Found for Echoviruses
- Source :
- Trends in microbiology. 27(6)
- Publication Year :
- 2019
-
Abstract
- Echoviruses are amongst the most common causative agents of aseptic meningitis worldwide and are particularly devastating in the neonatal population, where they are associated with severe hepatitis, neurological disease, including meningitis and encephalitis, and even death. Here, we identify the neonatal Fc receptor (FcRn) as a pan-echovirus receptor. We show that loss of expression of FcRn or its binding partner beta 2 microglobulin (β2M) renders cells resistant to infection by a panel of echoviruses at the stage of virus attachment, and that a blocking antibody to β2M inhibits echovirus infection in cell lines and in primary human intestinal epithelial cells. We also show that expression of human, but not mouse, FcRn renders nonpermissive human and mouse cells sensitive to echovirus infection and that the extracellular domain of human FcRn directly binds echovirus particles and neutralizes infection. Lastly, we show that neonatal mice expressing human FcRn are more susceptible to echovirus infection by the enteral route. Our findings thus identify FcRn as a pan-echovirus receptor, which may explain the enhanced susceptibility of neonates to echovirus infections.
- Subjects :
- Microbiology (medical)
Enterovirus Infections
Echovirus
viruses
Fc receptor
macromolecular substances
Receptors, Fc
medicine.disease_cause
ta3111
Microbiology
infektiot
complex mixtures
enteroviruses
03 medical and health sciences
Neonatal Fc receptor
Virology
medicine
Humans
vastasyntyneet
Receptor
030304 developmental biology
0303 health sciences
biology
030306 microbiology
ta1183
Histocompatibility Antigens Class I
ta1182
virus diseases
Infant
biochemical phenomena, metabolism, and nutrition
Biological Sciences
neonates
Enterovirus B, Human
enterovirukset
Infectious Diseases
biology.protein
Echovirus infections
ECHO-virukset
Echovirus Infections
Subjects
Details
- ISSN :
- 18784380
- Volume :
- 27
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Trends in microbiology
- Accession number :
- edsair.doi.dedup.....b6503edc800d7d1a54d6763560226578