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The Dual Role of Oat Bran Water Extract in Bone Homeostasis Through the Regulation of Osteoclastogenesis and Osteoblast Differentiation
- Source :
- Molecules, Vol 23, Iss 12, p 3119 (2018), Molecules, Volume 23, Issue 12
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- The number of patients with bone metabolic disorders including osteoporosis is increasing worldwide. These disorders often facilitate bone fractures, which seriously impact the patient&rsquo<br />s quality of life and could lead to further health complications. Bone homeostasis is tightly regulated to balance bone resorption and formation. However, many anti-osteoporotic agents are broadly categorized as either bone forming or anti-resorptive, and their therapeutic use is often limited due to unwanted side effects. Therefore, safe and effective therapeutic agents are needed for osteoporosis. This study aims to clarify the bone protecting effects of oat bran water extract (OBWE) and its mode of action. OBWE inhibited RANKL (receptor activator of nuclear factor-&kappa<br />B ligand)-induced osteoclast differentiation by blocking c-Fos/NFATc1 through the alteration of I-&kappa<br />B. Furthermore, we found that OBWE enhanced BMP-2-stimulated osteoblast differentiation by the induction of Runx2 via Smad signaling molecules. In addition, the anti-osteoporotic activity of OBWE was also evaluated using an in vivo model. OBWE significantly restored ovariectomy-induced bone loss. These in vitro and in vivo results showed that OBWE has the potential to prevent and treat bone metabolic disorders including osteoporosis.
- Subjects :
- Dietary Fiber
Male
0301 basic medicine
Cell signaling
Avena
Osteoporosis
Pharmaceutical Science
030209 endocrinology & metabolism
endocrinology_metabolomics
bone
Article
Bone resorption
Analytical Chemistry
lcsh:QD241-441
Mice
03 medical and health sciences
0302 clinical medicine
lcsh:Organic chemistry
Osteoclast
In vivo
Drug Discovery
medicine
Animals
Physical and Theoretical Chemistry
Mice, Inbred ICR
biology
Plant Extracts
business.industry
Organic Chemistry
Water
osteoblasts
Cell Differentiation
Osteoblast
medicine.disease
osteoporosis
RUNX2
030104 developmental biology
medicine.anatomical_structure
osteoclasts
Chemistry (miscellaneous)
RANKL
biology.protein
Cancer research
oat bran
Molecular Medicine
Female
business
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 23
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....b6458057dd0a87155ce9347636a5718a